Results 91 to 100 of about 3,140,461 (291)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Risk factor profiles and cognitive function in older adults: the Brain Health Support Program Study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
BACKGROUND Dementia risk factors coexist and interact in meaningful ways. Identifying risk profiles can inform prevention strategies. METHODS This study examined profiles using seven modifiable risk factors and their associations with cognition and sex ...
Caroline S. Duchaine, Manuel Montero‐Odasso, Haakon B. Nygaard, Paul W. H. Brewster, Diane M. Jacobs, Nicole D. Anderson, Penelope J. Slack, January M. Durant, Jody‐Lynn Lupo, Howard Chertkow, Howard H. Feldman, Sylvie Belleville, the Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN‐THUMBS UP Study Group   +12 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

A general framework for reinforcement learning in cognitive architectures

Recent advancements in reinforcement learning (RL), particularly deep RL, show the capacity of this paradigm to perform varied and complex tasks. However, a series of exploration, generalization, and adaptation challenges hold RL back from operating in ...
Gudwin, Ricardo, Simões, Alexandre [UNESP], Yuji, Eduardo, Morais, Gustavo, Costa, Paula, Colombini, Esther   +5 more
core   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Cognitive contact linguistics: placing usage, meaning and mind at the core of contact-induced variation and change Cognitive linguistics research ;, 62./ edited by Eline Zenner, Ad Backus, Esme Winter-Froemel.

, 2019
"The collection of papers presented in this volume, which grew out of a theme session organised at the 13th International Cognitive Linguistics Conference (Northumbria, UK, July 2015)"--Page vii.Includes bibliographical references and index.1 online ...
Backus Ad, Winter-Froemel Esme, Zenner Eline   +2 more
core  

UNDERSTANDING PREPOSITIONS THROUGH COGNITIVE GRAMMAR. A CASE OF IN [PDF]

, 2004
Poly - semantic nature of prepositions has been discussed in linguistic literature and confirmed by language data. In the majority of research within cognitive linguistics prepositions have been approached as predicates organising entities in space, with
Turewicz, prof. Kamila
core  

Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study

The Journal of Nutrition, Health and Aging
Background: Modifiable lifestyle behaviors significantly influence the risk of cognitive impairment. However, the cumulative effects of multidimensional lifestyle profiles on cognitive function remain poorly understood, as most studies examine individual
Huixiu Hu, Yajie Zhao, Di Guo, Ying Deng, Huanhuan Luo, Yuqing Hao, Chao Sun, Kang Yu   +7 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source