Results 41 to 50 of about 628,655 (303)

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Comparing factor mixture modeling and conditional Gaussian mixture variational autoencoders for cognitive profile clustering

Frontiers in Psychology
IntroductionUnderstanding individual cognitive profiles is crucial for developing personalized educational interventions, as cognitive differences can significantly impact how students learn.
Matteo Orsoni, Sara Giovagnoli, Sara Garofalo, Noemi Mazzoni, Matilde Spinoso, Mariagrazia Benassi   +5 more
doaj   +1 more source

Application of the RDoC Framework to Predict Alcohol Use and Suicidal Thoughts and Behaviors among Early Adolescents in the Adolescent Brain and Cognitive Development (ABCD) Study

Brain Sciences, 2022
Alcohol use confers risk for suicidal thoughts and behaviors (ideation, attempt) in early adolescents. The Research Domain Criteria provides a framework for examination of multidimensional and modifiable risk factors. We examined distinct latent profiles
Laika D. Aguinaldo, Clarisa Coronado, Diego A. Gomes, Kelly E. Courtney, Joanna Jacobus   +4 more
doaj   +1 more source

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source

Skill set profile clustering: the empty K-means algorithm with automatic specification of starting cluster centers [PDF]

, 2010
While students’ skill set profiles can be estimated with formal cognitive diagnosis models [8], their computational complexity makes simpler proxy skill estimates attractive [1, 4, 6].
Ayers, E., Dean, N., Nugent, R.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Stages of change profiles of offenders : exploring offenders' motivation to work on their offending problems : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Clinical Psychology at Massey University, Albany, New Zealand [PDF]

, 2017
Research has highlighted the importance of the stages of change (SoC) model (Prochaska, DiClemente, & Norcross, 1992) in assessing offenders’ motivation to work on their offending problems and as a guiding framework for selecting interventions.
Yong, Abigail Dawn
core  

Developmental Lead and/or Prenatal Stress Exposures Followed by Different Types of Behavioral Experience Result in the Divergence of Brain Epigenetic Profiles in a Sex, Brain Region, and Time-Dependent Manner: Implications for Neurotoxicology. [PDF]

, 2017
Over a lifetime, early developmental exposures to neurocognitive risk factors, such as lead (Pb) exposures and prenatal stress (PS), will be followed by multiple varied behavioral experiences.
Cory-Slechta, Deborah A., Schneider, Jay S., Sobolewski, Marissa, Varma, Garima   +3 more
core   +2 more sources

Cognitive profiles across the psychosis continuum [PDF]

Psychiatry Research
Cognitive impairments are core features in individuals across the psychosis continuum and predict functional outcomes. Nevertheless, substantial variability in cognitive functioning within diagnostic groups, along with considerable overlap with healthy controls, hampers the translation of research findings into personalized treatment planning.
Tina D. Kristensen, Fabian M. Mager, Karen S. Ambrosen, Anita D. Barber, Cecilie K. Lemvigh, Kirsten B. Bojesen, Mette Ø. Nielsen, Birgitte Fagerlund, Birte Y. Glenthøj, Warda T. Syeda, Louise B. Glenthøj, Bjørn H. Ebdrup   +11 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source