Results 91 to 100 of about 227,180 (304)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Semantic Memory Functional MRI and Cognitive Function After Exercise Intervention in Mild Cognitive Impairment [PDF]

, 2013
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer\u27s disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD.
Antuono, Piero, Butts, Alissa, Hanson, Ryan J., Hantke, Nathan, Lyons, Jeri-Annette, Nielson, Kristy A., Smith, J Carson, Verber, Matthew D.   +7 more
core   +2 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis

Scientific Reports
Recent research has shown that cognitive reserve is associated with better cognitive abilities in ALS/MND, and that a slow brain ageing speed is associated with intact cognition in ALS.
Anna G. M. Temp, Gaël Nils Tarakdjian, Elisabeth Kasper, Judith Machts, Jörn Kaufmann, Stefan Vielhaber, Johannes Prudlo, James H. Cole, Martin Dyrba, Stefan Teipel, Andreas Hermann   +10 more
doaj   +1 more source

Sex differences in the association between episodic memory residual reserve index and change in executive function

Aging Brain
Sex differences in cognitive reserve might contribute to females being disproportionately affected by Alzheimer’s disease (AD). We investigated sex differences in the protective effects of cognitive reserve, and whether brain beta-amyloid accounts for ...
Cheyenne Chooi, Brandon E. Gavett, David Ames, Paul Maruff, Vincent Doré, Victor L. Villemagne, Pierrick Bourgeat, Ying Xia, Colin L. Masters, Ralph N. Martins, Kevin Taddei, Christopher C. Rowe, Michael Weinborn, Stephanie R. Rainey-Smith   +13 more
doaj   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. [PDF]

, 2020
In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer's Disease Neuroimaging Initiative participants, we fit a linear model with Rey ...
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Digma, Leonardino A, Jacobs, Diane M, Madsen, John R, Rissman, Robert A   +6 more
core  

Cognitive reserve in young-onset cognitive impairment

Brain and Cognition
Cognitive reserve (CR) reflects brain's resilience to pathology, enabling to maintain function despite structural damage. This study investigates its role in young-onset cognitive impairment (
Chiara Carbone, Riccardo Maramotti, Erica Balboni, Daniela Beltrami, Daniela Ballotta, Roberta Bedin, Chiara Gallingani, Manuela Tondelli, Simone Salemme, Federico Gasparini, Giulia Vinceti, Alessandro Marti, Annalisa Chiari, Luca Nocetti, Giuseppe Pagnoni, Giovanna Zamboni   +15 more
openaire   +2 more sources

Cerebral correlates of cognitive reserve

Psychiatry Research: Neuroimaging, 2016
Cognitive reserve is a hypothetical concept introduced to explain discrepancies between severity of clinical dementia syndromes and the extent of dementia pathology. We examined cognitive reserve in a research programme that followed up a non-clinical sample born in 1921 or 1936 and IQ-tested age 11 years in 1932 or 1947.
Whalley, Lawrence J., Staff, Roger T., Fox, Helen C., Murray, Alison D.   +3 more
openaire   +4 more sources