Results 71 to 80 of about 227,180 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients

Frontiers in Aging Neuroscience
BackgroundCognitive decline is common after stroke. This study assessed the longitudinal associations between cognitive reserve and post-stroke cognitive function and tested whether these associations differ across patients’ stroke severity.MethodsA ...
Yinuo Ou, Yinuo Ou, Yanrong Zhang, Yalin Lv, Yalin Lv, Silian Ding, Xiangjing Kong, Hanzhang Xu, Hanzhang Xu, Bei Wu, Hui Wei, Juan Li, Juan Li   +12 more
doaj   +1 more source

Social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis

European Psychiatry, 2021
Introduction Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve.
I. González-Ortega, S. Alberich-Mesa, E. Echeburúa, M. Bernardo, B. Cabrera, S. Amoretti, A. Lobo, C. Arango, I. Corripio, E. Vieta, E. De La Serna, R. Rodriguez-Jimenez, R. Segarra, J.M. López-Ilundain, A. Sánchez-Torres, M. Cuesta, A. González-Pinto   +16 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A measure of modifiable lifestyle factors shaping subjective cognitive reserve in the general population

Frontiers in Psychology
ObjectiveThis study examined the psychometric properties of a newly developed scale for measuring subjective cognitive reserve (SCR) across multiple domains, including nutrition, physical condition, sleep, cognition, willingness to learn, socialization ...
Carmen Moret-Tatay, Carmen Moret-Tatay, José María Tormos Muñoz, José María Tormos Muñoz, Alvaro Pascual-Leone, Alvaro Pascual-Leone   +5 more
doaj   +1 more source

Exercise Training and Functional Connectivity Changes in Mild Cognitive Empairment and Healthy Elders [PDF]

, 2016
Background: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer’s disease (AD).
Alfini, Alfonso J., Carson, J. Smith, Chirles, Theresa J., Nielson, Kristy A., Reiter, Katherine, Weiss, Lauren R.   +5 more
core   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Coordinated analysis of age, sex, and education effects on change in MMSE scores [PDF]

, 2012
Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of
A. M. Piccinin, A. Mackinnon, A. Spiro, Aevarsson, Alley, Anstey, B. Johansson, Butler, C. A. Reynolds, Christensen, Christensen, Colsher, Colsher, Crane, D. J. H. Deeg, DerSimonian, Enders, Evans, Farmer, Folstein, G. Muniz-Terrera, GEERLINGS, Gibbons, Glymour, Glymour, Hofer, Huisman, I. J. Deary, I. Skoog, J. M. Starr, Jacqmin-Gadda, Lyketsos, Manly, Pedersen, Pfeiffer, Rinder, S. Clouston, S. M. Hofer, Skoog, Stern, Svanborg, Terrera, Tucker-Drob, V. Thorvaldsson, Van Dijk, Wainer, Zahodne   +46 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The association between cognitive reserve and time to conversion from normal cognition to mild cognitive impairment [PDF]

, 2016
Mild cognitive impairment (MCI) is a subclinical cognitive decline in the elderly that increases the risk of conversion to Dementia. Delaying the onset of conversion from normal cognition to MCI has public health relevance by potentially reducing the ...
Malave, Ryan
core