Results 21 to 30 of about 475,355 (258)

Effects of computerized cognitive training on neuroimaging outcomes in older adults: a systematic review

BMC Geriatrics, 2017
Background Worldwide, the population is aging and the number of individuals diagnosed with dementia is rising rapidly. Currently, there are no effective pharmaceutical cures.
Lisanne F. ten Brinke, Jennifer C. Davis, Cindy K. Barha, Teresa Liu-Ambrose   +3 more
doaj   +1 more source

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Prenatal psychosocial factors and changes in marital satisfaction after childbirth: an online cohort study of pregnant women

BMC Pregnancy and Childbirth
Background Marital satisfaction is a key determinant of maternal mental health during the perinatal period. Identifying psychosocial factors associated with changes in marital satisfaction can help inform early preventive interventions.
Chika Kubota, Chika Yokoyama, Haruna Irino, Yasue Mitamura, Aiko Okatsu, Satoko Sasagawa, Ayako Kanie, Aiichiro Nakajima, Miyuki Makino, Sayaka Aoyama, Yaeko Kataoka, Masaru Horikoshi, Hironori Kuga, Masaya Ito   +13 more
doaj   +1 more source

Effects of Cancer Treatment on Somatosensory and Nociceptive Processing in Children and Adolescents: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chemotherapy‐induced peripheral neuropathy remains a major complication in pediatric cancer, with disrupted somatosensory and nociceptive processing being a key aspect. This review synthesizes empirical studies on alterations in somatosensory and nociceptive processing in children and adolescents with cancer.
Julia Schweiger, Laura Walz, Michael C. Frühwald, Stefan Lautenbacher, Miriam Kunz   +4 more
wiley   +1 more source

Systemic therapy informed self-help and paraprofessional training in a naturalistic setting: study protocol of a digital randomised trial

Archives of Public Health
Background Multiple studies have shown the efficacy of Systemic Psychotherapy (ST) approaches as a promising path to address various mental health disorders and alleviate psychological distress.
Pieter Erasmus, Moritz Borrmann, Ayesha Tariq Ali, Stefanie Herta, Jule Becker, Glen Moriarty, Gunther Meinlschmidt   +6 more
doaj   +1 more source

Daily blood pressure profile and blood–brain barrier permeability in patients with cerebral small vessel disease

Scientific Reports, 2022
Cerebral small vessel disease (CSVD) plays an important role in cognitive impairment, stroke, disability, and death. Hypertension is the main risk factor for CSVD.
L. A. Dobrynina, K. V. Shamtieva, E. I. Kremneva, M. R. Zabitova, B. M. Akhmetzyanov, E. V. Gnedovskaya, M. V. Krotenkova   +6 more
doaj   +1 more source

Implementation and Evaluation of Therapeutic Online Coaching Using Habit Reversal Training in Children With Tourette’s Disorder – A Pilot Study

Frontiers in Psychology, 2021
Cognitive-behavioral interventions can be difficult to implement in daily routine, which is often essential for generalizing treatment effects to natural settings.
Paula Viefhaus, Julia Adam, Hildegard Goletz, Katrin Woitecki, Manfred Döpfner, Manfred Döpfner   +5 more
doaj   +1 more source

Criterion‐Related Validity of the Neuropsychological Quick Assessment for Screening Cognitive, Motor, and Behavioral Impairments in Patients With Pediatric Brain Tumors: An Observational Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neuropsychological complications may impair the qualitative prognosis of patients with pediatric brain tumors. However, multifaceted evaluations cannot be conducted in all patients because they are time consuming and burdensome for patients.
Ami Tabata, Keita Ueda, Tsukasa Ueno, Katsutsugu Umeda, Kentaro Ueno, Kanade Tanaka, Noyuri Nishida, Rie Yamawaki, Megumi Nukui, Yoshiki Arakawa   +9 more
wiley   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source