Results 41 to 50 of about 580,232 (316)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Implementation and Evaluation of Therapeutic Online Coaching Using Habit Reversal Training in Children With Tourette’s Disorder – A Pilot Study

Frontiers in Psychology, 2021
Cognitive-behavioral interventions can be difficult to implement in daily routine, which is often essential for generalizing treatment effects to natural settings.
Paula Viefhaus, Julia Adam, Hildegard Goletz, Katrin Woitecki, Manfred Döpfner, Manfred Döpfner   +5 more
doaj   +1 more source

Cognitive therapy for depression [PDF]

British Medical Bulletin, 2001
AbstractThere is considerable empirical support for the use of cognitive therapy in the treatment of mild to moderately severe acute major depression. More recent research has focused on the utility of this approach in severe or chronic depressive disorders, in relapse prevention and also on the potential benefits of combining cognitive therapy with ...
openaire   +2 more sources

Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy

, 2002
Background. While there is a growing body of evidence on the efficacy of psychological interventions for schizophrenia, this meta-analysis improves upon previous systematic and meta-analytical reviews by including a wider range of randomized controlled ...
Pilling, S., Geddes, J., Morgan, C, Geddes, J, Kuipers, E, Bebbington, P., Garety, P, Morgan, C., Orbach, G., Garety, P., Bebbington, P, Garety, P; id_orcid, Pilling, S, Orbach, G, Kuipers, E; id_orcid, Kuipers, E.   +15 more
core   +1 more source

Using computers to teach people with intellectual disabilities to perform some of the tasks used within cognitive behavioural therapy: a randomised experiment [PDF]

, 2015
Aims: Training has been shown to improve the ability of people with intellectual disabilities (IDs) to perform some cognitive behavioural therapy (CBT) tasks.
Vereenooghe, Leen, Langdon, Peter E., Gega, Lina, Reynolds, Shirley, Langdon, Peter, Vereenooghe, Leen ; https://orcid.org/   +5 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis

, 2012
Background: Prepulse inhibition (PPI) of the startle response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus.
Peters, Emmanuelle R., Emmanuelle R. Peters, Peters, Emmanuelle R.; id_orcid, Antonova, Elena, Preethi Premkumar, Kuipers, Elizabeth; id_orcid, Satya Raghuvanshi, Aasen, I, Kumari, V, Antonova, E, Ingrid Aasen, Kuipers, Elizabeth, Elizabeth Kuipers, Elena Antonova, Aasen, Ingrid, Premkumar, P, Anilkumar, AP, Kuipers, E, Anilkumar, Anantha P., Peters, ER, Veena Kumari, Fannon, D, Raghuvanshi, Satya, Kumari, Veena, Anantha P. Anilkumar, Dominic Fannon, Raghuvanshi, S, Fannon, Dominic, Premkumar, Preethi   +28 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Are Changes in Worry Associated with Treatment Response in Cognitive Behavioral Therapy for Insomnia?

, 2014
Aim: Little is known about why some patients respond to cognitive behavioral therapy for insomnia, whereas other patients do not. To understand differences in treatment response, there is a dire need to examine processes of change.
Sunnhed, Rikard,, Jansson-Fröjmark, Markus,   +1 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source