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Uses of coherent Raman scattering microscopy in neuroscience [PDF]
Frontiers in NeuroscienceMultiphoton microscopy allows the imaging of biological phenomena deep within brain tissues and has greatly advanced knowledge in neuroscience. However, many optical phenomena other than the multiphoton excitation of fluorophores in nonlinear optics are ...
Mutsuo Nuriya, Mutsuo Nuriya
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Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research [PDF]
Frontiers in Pharmacology, 2021 The high attrition rates of anti-cancer drugs during clinical development remains a bottleneck problem in pharmaceutical industry. This is partially due to the lack of quantitative, selective, and rapid readouts of anti-cancer drug activity in situ with ...
Junjie Zeng +3 more
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Coherent Stokes Raman scattering microscopy (CSRS)
Nature Communications, 2023 We report the first implementation of laser scanning coherent Stokes Raman scattering (CSRS) microscopy. To overcome the major challenge in CSRS imaging, we show how to suppress the fluorescence background by narrow bandpass filter and a lock-in based ...
Sandro Heuke, Hervé Rigneault
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Broadband Coherent Raman Scattering Microscopy [PDF]
Laser and Photonics Reviews, 2018 AbstractSpontaneous Raman (SR) microscopy allows label‐free chemically specific imaging based on the vibrational response of molecules; however, due to the low Raman scattering cross section, it is intrinsically slow. Coherent Raman scattering (CRS) techniques, by coherently exciting vibrational oscillators in the focal volume, increase signal levels ...
Marco Marangoni +2 more
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Coherent Raman Scattering Microscopy in Biology and Medicine [PDF]
Annual Review of Biomedical Engineering, 2015 Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS microscopy is the dramatic improvement in imaging speed, which gives rise to real-time vibrational imaging of live
Ji-Xin Cheng, Chi Zhang, Delong Zhang
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Biological imaging with coherent Raman scattering microscopy: a tutorial. [PDF]
J Biomed Opt, 2014 Coherent Raman scattering (CRS) microscopy is gaining acceptance as a valuable addition to the imaging toolset of biological researchers. Optimal use of this label-free imaging technique benefits from a basic understanding of the physical principles and technical merits of the CRS microscope.
Alfonso-García A +3 more
europepmc +8 more sources
Coherent anti‐Stokes Raman Scattering Microscopy [PDF]
ChemPhysChem, 2007 AbstractCoherent anti‐Stokes Raman scattering (CARS) microscopy is presented as a new nonlinear optical technique. The combination of vibrational spectroscopy and microscopy allows highly sensitive investigations of unlabelled samples. CARS is an ideal tool for studying a broad variety of samples.
Müller, M., Zumbusch, A.
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Coherent Raman Scattering Microscopy for Evaluation of Head and Neck Carcinoma [PDF]
Otolaryngology - Head and Neck Surgery, 2017 ObjectiveWe aim to describe a novel, label‐free, real‐time imaging technique, coherent Raman scattering (CRS) microscopy, for histopathological evaluation of head and neck cancer. We evaluated the ability of CRS microscopy to delineate between tumor and nonneoplastic tissue in tissue samples from patients with head and neck cancer.Study ...
Daniel Orringer, Matthew Spector
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Dissecting lipid droplet biology with coherent Raman scattering microscopy. [PDF]
J Cell Sci, 2022 ABSTRACT Lipid droplets (LDs) are lipid-rich organelles universally found in most cells. They serve as a key energy reservoir, actively participate in signal transduction and dynamically communicate with other organelles. LD dysfunction has been associated with a variety of diseases. The content level, composition and mobility of LDs are
Chen T, Yavuz A, Wang MC.
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Coherent Raman scattering microscopy of lipid droplets in cells and tissues. [PDF]
J Raman Spectrosc, 2023 AbstractLipid droplets (LDs) play a key role as the hub for lipid metabolism to maintain cellular metabolic homeostasis. Understanding the functions and changes of LDs in different pathological conditions is crucial for identifying new markers for diagnosis and discovering new targets for treatment.
Zhang C.
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