Results 71 to 80 of about 14,454,704 (305)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Стохастическая двумодовая эредитарная модель космического динамо

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
Работа посвящена классу стохастических двумодовых эредитарных моделей космического динамо. Модели включают в себя два генератора магнитного поля — крупномасштабный и турбулентный (α-эффект).
Казаков, Е.А., Водинчар, Г.М.   +1 more
doaj   +1 more source

Coherence, focus and structure [PDF]

Pragmatics. Quarterly Publication of the International Pragmatics Association (IPrA), 2022
This paper examines the usage of NE in Chinese dialogues and monologues excerpted from a Chinese collection of narratives. The analysis of NE as a constituent in discourse structure shows that linguistically it functions like a grammatical connector. From a cognitive point of view, NE signals topic shift and focuses on new, contrastive information.
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An LES Investigation of Flow Field Around the Cuboid Artificial Reef at Different Angles of Attack

Journal of Marine Science and Engineering
The placement of artificial reefs (ARs) significantly influences local hydrodynamics and nutrient transport, both of which are crucial for enhancing marine ecosystems and improving marine habitats. Large eddy simulations (LESs) are performed to study the
Jie Dai, Qianshun Xu, Yiqing Gong, Yang Lu, Xinbo Liu, Jingqiao Mao   +5 more
doaj   +1 more source

Resolution Dependence of Turbulent Structures in Convective Boundary Layer Simulations

Atmosphere, 2020
Large-eddy simulations are performed using the U.K. Met Office Large Eddy Model to study the effects of resolution on turbulent structures in a convective boundary layer. A standard Smagorinsky subgrid scheme is used. As the grid length is increased, the
Mary-Jane M. Bopape, Robert S. Plant, Omduth Coceal   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Large eddy simulation of film cooling on turbine vane

Journal of Thermal Science and Technology, 2019
Large eddy simulations were performed for film cooling on scaled-up C3X turbine vane at the nominal blowing ratio of M=0.5~1.5, and the Reynolds number, Re=3000, based on the mainstream inlet velocity and hole diameter.
Fangsu FAN, Chunhua WANG, Jingzhou ZHANG
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

LCS Tool: A computational platform for Lagrangian coherent structures [PDF]

Journal of Computer Science, 2014
We give an algorithmic introduction to Lagrangian coherent structures (LCSs) using a newly developed computational engine, LCS Tool. LCSs are most repelling, attracting and shearing material lines that form the centerpieces of observed tracer patterns in
Kristjan Onu, F. Huhn, G. Haller
semanticscholar   +1 more source