Results 71 to 80 of about 19,278,057 (340)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Lagrangian flow measurements and observations of the 2015 Chilean tsunami in Ventura, CA

Geophysical Research Letters, 2016
Tsunami‐induced coastal currents are spectacular examples of nonlinear and chaotic phenomena. Due to their long periods, tsunamis transport substantial energy into coastal waters, and as this energy interacts with the ubiquitous irregularity of ...
Nikos Kalligeris, Vassilios Skanavis, Sasan Tavakkol, Aykut Ayca, Hoda El Safty, Patrick Lynett, Costas Synolakis   +6 more
doaj   +1 more source

On the Experimental, Numerical and Data-Driven Methods to Study Urban Flows

Energies, 2021
Understanding the flow in urban environments is an increasingly relevant problem due to its significant impact on air quality and thermal effects in cities worldwide.
Pablo Torres, Soledad Le Clainche, Ricardo Vinuesa   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Automatic eduction and statistical analysis of coherent structures in the wall region of a confine plane [PDF]

, 2006
This paper describes a vortex detection algorithm used to expose and statistically characterize the coherent flow patterns observable in the velocity vector fields measured by Particle Image Velocimetry (PIV) in the impingement region of air curtains ...
Pavageau, Michel, Gupta, S., Loubière, Karine, Gupta, Sanjeev, Pavageau, M., Loubière, K.   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Interactions Between Coherent Structures and the Urban Canopy Layer [PDF]

, 2014
The focus of this dissertation research is to gain further insight into the interaction of coherent structures and the urban canopy layer (CS-UCL interactions). There is a growing body of evidence that suggests that periods of strong turbulence transport
Arms, Sean
core  

Deformation of coherent structures [PDF]

Reports on Progress in Physics, 1996
In this review we investigate the mathematical description of the distortion of clearly recognisable structures in phenomenological physics. The coherent structures we will explicitly deal with are surface waves on a layer of fluid, kink transitions in magnetic material, plane vortices, swirling flows in cylindrical pipes and periodic patterns in ...
Fledderus, E.R., van Groesen, E.
openaire   +2 more sources

Derivation and Implementation of a Non‐Local Term to Improve the Oceanic Convection Representation Within the k–ɛ Parameterization

Journal of Advances in Modeling Earth Systems
The representation of turbulent fluxes during oceanic convective events is important to capture the evolution of the oceanic mixed layer. To improve the accuracy of turbulent fluxes, we examine the possibility of adding a non‐local component in their ...
Alexandre Legay, Bruno Deremble, Hans Burchard   +2 more
doaj   +1 more source

Control Parameters for Boundary-Layer Instabilities in Unsteady Shock Interactions

Entropy, 2012
This article presents the computation of a set of control parameters for the deterministic prediction of laminar boundary-layer instabilities induced by an imposed unsteady shock interaction.
LaVar King Isaacson
doaj   +1 more source