Results 31 to 40 of about 119,327 (310)

Infinite Descent [PDF]

open access: yes, 2020
Once one accepts that certain things metaphysically depend upon, or are metaphysically explained by, other things, it is natural to begin to wonder whether these chains of dependence or explanation must come to an end.
Dixon, T. Scott
core   +1 more source

Will Evers and Lakomski be able to find leadership’s Holy Grail?

open access: yesKEDI Journal of Educational Policy, 2012
In this paper I intend to have a critical look at the theory development issues in the field of educational administration and leadership with a special emphasis on Colin Evers and Gabriel Lakomski’s naturalistic direction.
Kadir Beycioglu
doaj   +1 more source

Models, Brains, and Scientific Realism [PDF]

open access: yes, 2006
Prediction Error Minimization theory (PEM) is one of the most promising attempts to model perception in current science of mind, and it has recently been advocated by some prominent philosophers as Andy Clark and Jakob Hohwy. Briefly, PEM maintains that “
Sterpetti, Fabio
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Wittgenstein on the Structure of Justification: Breaking New Epistemological Ground [PDF]

open access: yes, 2003
I shall investigate Wittgenstein's view of the structure of justification comparing it to Foundationalism, Holistic Coherentism, and Contextualism. Remarks in On Certainty (1969) appear to commit Wittgenstein to each of these theories, and scholars have ...
Caraway, Carol
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

THE PROBLEM OF LEGAL VALIDITY IN THE ANTI-METAPHYSICAL APPROACH (ALF ROSS’S CONCEPTION)

open access: yesRUDN Journal of Law, 2017
The article analyzes the main approaches to the problem of the validity of law. As a result a num-ber of aspects of the phenomenon designated as “the validity of law” are distinguished: normative sig-nificance, social and (or) psychological efficiency ...
Natalia S Vasilyeva
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The philosophy of total evidence and its relevance for phylogenetic inference

open access: yesPapéis Avulsos de Zoologia, 2005
The test of congruence under total evidence as used in systematics has been tied to a Popperian philosophy of science, but is here shown to be related to the coherence theory of truth in metaphysics and thus to coherentism in epistemology. Since the test
Olivier Rieppel
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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