Results 41 to 50 of about 907,950 (295)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Moving on from ‘anti-racism’? Understandings of ‘community cohesion’ held by youth workers [PDF]
, 2007 ‘Community Cohesion’, and the apparent lack of it, was rapidly offered as the explanation for the 2001 disturbances across northern England, and has since become a cornerstone of government approaches to race relations policy.
Thomas, Paul
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mapping Social Cohesion Survey, 2009
, 2018 The Social Cohesion Survey is a series of detailed surveys on social cohesion, immigration and population issues. A prime objective of the surveys is to further understanding of the social impact of Australia's increasingly diverse immigration program ...
Markus, Andrew, Smith, Bruce
core +1 more source
The impact of community cohesion on youth work: A case study from Oldham [PDF]
, 2006 Initiated by the 2001 disturbances in Oldham, Burnley and Bradford, 'community cohesion' offers a critique of the apparently negative race relations in many of Britain's towns and cities.
Thomas, Paul
core +4 more sources
Entrepreneurial performance of the European Union - pivot of its economic security
New Medit, 2020 "The goal of the present paper is to demonstrate whether the varying performance of the European Union states in terms of business and entrepreneurial attractiveness and activity is diminishing the level of overall economic security.
Augustin Ignatov
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mapping Social Cohesion Survey, 2010
, 2018 The Social Cohesion Survey is a series of detailed surveys on social cohesion, immigration and population issues. A prime objective of the surveys is to further understanding of the social impact of Australia's increasingly diverse immigration program ...
Markus, Andrew, Smith, Bruce
core +1 more source
Local Passion, National Indifference: Implementing Community Cohesion policies in Northern England [PDF]
The emergence of Community Cohesion (Cantle, 2001) as national policy from 2001 was portrayed as the ‘death of multiculturalism’ in Britain (Kundnani, 2002).
Thomas, Paul
core +4 more sources