Results 61 to 70 of about 263,450 (342)
The Journal of Cell Biology, 2001 ![Graphic][1] Cohesin (red) keeps centromeres together. Peters/AAAS Cohesin was a long sought-after protein complex: a glue for sister chromatids that is dissolved at the onset of anaphase thanks to cleavage of its SCC1 subunit by the protease separase.
openaire +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
FEBS Open Bio, EarlyView.The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi +2 more
wiley +1 more source
Detecting rs‐fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Preserved resting‐state functional MRI (rs‐fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs‐fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice.
Jean Paul Medina Carrion +15 more
wiley +1 more source
Psychological Medicine, 2019 Background Exposure to stressful life events is an established risk factor for the development of adolescent mental disorder. Growing evidence also suggests that neighbourhood social environments, including strong social cohesion, could have a protective
M. Kingsbury +3 more
semanticscholar +1 more source
The Diagnostic Value of Visual Evoked Potentials in Chronic Disorders of Consciousness
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In chronic disorders of consciousness (DOCs), the distinction between vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state (MCS) is as crucial as it is challenging. Evoked potentials (EPs) and event‐related potentials (ERPs) are helpful, but some limitations prevent their consistent use in the ...
Letizia Clementi +14 more
wiley +1 more source
Extreme overvalued beliefs and identities: revisiting the drivers of violent extremism
Frontiers in PsychologyRecent efforts to understand violent extremism have appealed to the concept of extreme overvalued beliefs as a way of explaining fixation and extremist commitments.
Kolbrun Kristinsdottir +5 more
doaj +1 more source
E.U.’s Strategy of Building a Knowledge Economy
Studies and Scientific Researches: Economics Edition, 2012 The European Union strategy for building knowledge-based economy includes a set of objectives, priority action areas, targets and measures to guide European policy for growth and employment.
Roxana Mironescu, Andreea Feraru
doaj +1 more source
Human Molecular Genetics, 2019 Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10.
A. J. Lara Ordóñez +11 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aimed to investigate the comparative effectiveness of standard versus personalized extended interval dosing of anti‐CD20 therapy on clinical and sub‐clinical outcomes in multiple sclerosis. Methods Clinical information was collected prospectively on Research Electronic Data Capture.
Nabil K. El Ayoubi +6 more
wiley +1 more source