Results 141 to 150 of about 3,608,670 (316)

Child inhibitory control in toddlerhood: associations with child interaction skills with the mother

BMC Psychology
Childhood inhibitory control (IC) is a key precursor of later social development, yet the mechanisms through which IC contributes to emerging interaction skills in toddlerhood remain insufficiently understood. We explored the cross-sectional associations
Pauliina Juntunen, Riikka Korja, Jetro J. Tuulari, Eeva Eskola, Eeva Holmberg, Anniina Karonen, Marika Otranen, Elmo P. Pulli, Eeva-Leena Kataja, David J. Bridgett, Hasse Karlsson, Linnea Karlsson, Saara Nolvi   +12 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy

, 2008
OBJECTIVE: To assess the long-term effect of HAART on non-Hodgkin lymphoma (NHL) incidence in people with HIV (PHIV). DESIGN: Follow-up of the Swiss HIV Cohort Study (SHCS). METHODS: Between 1984 and 2006, 12 959 PHIV contributed a total of 75 222 person-
Rickenbach, Martin, Battegay, Manuel, Swiss, HIV Cohort Study, Franceschi, S., Rickenbach, M, Furrer, H, Polesel, J., Schmid, P, Levi, F., Probst-Hensch, Nicole M., Bouchardy, C., Clifford, G. M., Franceschi, Silvia, Dal Maso, Luigino, Hasse, B, Battegay, M., Probst-Hensch, Nicole M, Bouchardy, Christine, Swiss HIV Cohort Study, Rickenbach, M., Probst-Hensch, N M, Schmid, Patrick, Levi, F, Clifford, G M, Polesel, J, Furrer, Hansjakob, Hasse, Barbara, Schmid, P., Bouchardy, C, Franceschi, S, Furrer, H., Probst-Hensch Nicole, M., Clifford, Gary M., Dal Maso, L., Dal Maso, L, Hasse, B., Probst-Hensch, N. M., Levi, Fabio, Clifford Gary, M., Clifford, Gary M, Battegay, M, Bouchardy Magnin, Christine, Polesel, Jerry   +42 more
core   +1 more source

Multi-stream deep learning framework integrating images and feature representations to predict mild cognitive impairment using the rey complex figure test

Scientific Reports
Drawing tests like the Rey complex figure test (RCFT) are widely used to assess cognitive functions such as visuospatial skills and memory, making them valuable tools for detecting mild cognitive impairment (MCI).
Junyoung Park, Eun Hyun Seo, Sunjun Kim, SangHak Yi, Kun Ho Lee, Sungho Won   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Cohort Profile: The Puberty Cohort in the Danish National Birth Cohort (DNBC) [PDF]

International Journal of Epidemiology, 2019
Cecilia H Ramlau-Hansen, Jørn Olsen, Inger K Meder, Erik T Parner, Anne-Marie Nybo Andersen, Ellen A Nohr, Bodil H Bech, Katrine Strandberg-Larsen, Lea L B Lauridsen, Nis Brix, Andreas Ernst   +10 more
openaire   +5 more sources

Trimester-specific association of maternal prenatal physical activities with risk of preterm birth: a prospective pre-birth cohort study

BMC Pregnancy and Childbirth
This study aimed to examine the trimester-specific association of maternal prenatal physical activities (PA) with risk of preterm birth (PTB). We recruited 2080 women during the first trimester and conducted follow-ups during the second and third ...
Jiajin Hu, Yanan Ma, Wenhan Jia, Ningyu Wan, Xiaochuan Wang, Lu Zheng, Zhe Yang, Dongming Zheng, Jun Wei, Deliang Wen   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source