Results 141 to 150 of about 4,817,088 (306)
Leadership development programme: a multi-method evaluation [PDF]
, 2013 This report investigates findings arising from a variety of forms of feedback provided by the first cohort of participants (2012-2013) in Cumbria Partnership Foundation Trust’s “Leadership Development” Programme (LDP).
Bargh, Melissa +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Estimating linear birth cohort effects: revisiting the age-happiness profile [PDF]
, 2007 This paper provides a simple way of accounting for linear birth cohort effects, together with linear age and calendar time effects. It relies on the discreteness of the data and on the fact that not all individuals are born/interviewed in the same day ...
Santos, Cristina
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Modelling the cohort effect in CBD models using a piecewise linear approach [PDF]
, 2012 This paper discusses a new pattern of mortality model which is built on the form and knowledge of the two-factor mortality model named after its designers Cairns, Blake and Dowd (2006).
Sweeting, Paul, Zhao, Yiwei
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The FinnBrain multimodal neonatal template and atlas collection
Communications BiologyThe accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not.
Jetro J. Tuulari +18 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A diminishing population whose every cohort more than replaces itself [PDF]
We observe that a dynamic population model can have period fertility that is always below replacement and cohort fertility that is always above replacement.
Robert Schoen, Stefan H. Jonsson
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source