Results 151 to 160 of about 2,602,200 (268)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Development and validation of an explainable artificial intelligence model to predict in-hospital adverse events for patients with acute myocardial infarction. [PDF]

PLOS Digit Health
Tian X, Ji M, Wang T, Yang Y, Yuan P, Zhang Y, Zhu C, Xia J, Gu Y, Liu H.   +9 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Age-Period-Cohort Analysis on Diabetes Awareness among Koreans: 2010-2023 Korea Community Health Surveys. [PDF]

Yonsei Med J
Hwang HA, Jeong H, Koo JW, Kim HS, Bae S, Jung SJ, Yim HW.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Echocardiography-led multimodal assessment for pulmonary hypertension in a right heart catheterization-referred cohort: incremental value of ECG and natriuretic peptides. [PDF]

Cardiovasc Ultrasound
Gao Y, Chen W, Ou J, Tao Q, Zhuang W.
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Baltic Sea microbial cohorts exhibit catabolic specialization and anabolic interdependencies across environmental gradients. [PDF]

PeerJ
Pacheco-Valenciana A, Milke F, Wienhausen G, Garcia SL.   +3 more
europepmc   +1 more source

Cohort Profile: The Copenhagen Child Cohort Study (CCC2000) [PDF]

International Journal of Epidemiology, 2019
Anne Mette Skovgaard, Torben Jørgensen, Michael Larsen, Inger Christine Munch, Allan Linneberg, Martin K Rimvall, Mathias Hvidtfelt Hansen, Xiao Qiang Li, Anja Munkholm, Lars Clemmensen, Pia Jeppesen, Hanne Elberling, Charlotte Ulrikka Rask, Else Marie Olsen   +13 more
openaire   +6 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source