Results 161 to 170 of about 5,101,614 (337)

P3.13D.09 Prevalence and Prognostic Impact of SEZ6 Expression in a Real-World Cohort of Patients with Small-Cell Lung Cancer [PDF]

Shui Wang, Aiping Luo, Nusrat Choudhury, L. Wang, Dongsheng Xu, Fang Jiang, Lisa Roberts-Rapp, Yookyung Christy Choi, Meng Cai, Nandini Rudra-Ganguly, Peter Ansell, L. Paz-Ares, L.A. Byers   +12 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Novel Pathogenic Variants in a French Cohort Widen the Mutational Spectrum of GNE Myopathy

, 2015
Mathieu Cérino, Svetlana Gorokhova, Anthony Béhin, Jon Andoni Urtizberea, Virginie Kergourlay, Eric Salvo, Rafaëlle Bernard, Nicolas Lévy, Marc Bartoli, Martin Krahn   +9 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Screening mammography performance according to breast density: a comparison between radiologists versus standalone intelligence detection

Breast Cancer Research
Background Artificial intelligence (AI) algorithms for the independent assessment of screening mammograms have not been well established in a large screening cohort of Asian women.
Mi-ri Kwon, Yoosoo Chang, Soo-Youn Ham, Yoosun Cho, Eun Young Kim, Jeonggyu Kang, Eun Kyung Park, Ki Hwan Kim, Minjeong Kim, Tae Soo Kim, Hyeonsoo Lee, Ria Kwon, Ga-Young Lim, Hye Rin Choi, JunHyeok Choi, Shin Ho Kook, Seungho Ryu   +16 more
doaj   +1 more source

Mortality and Costs Associated with Wearable Cardioverter-defibrillators after Acute Myocardial Infarction: A Retrospective Cohort Analysis of Medicare Claims Data

, 2019
Galen Kabulski, Amanda Northup, Barbara S. Wiggins   +2 more
openalex   +1 more source

Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients [PDF]

, 2021
Carlos Loucera, María Peña-Chilet, Marina Esteban‐Medina, Dolores Muñoyerro-Muñiz, Román Villegas, José López‐Miranda, Jesús Rodríguez‐Baño, Isaac Túnez, Roger Bouillon, Joaquı́n Dopazo, José Manuel Gómez   +10 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Long‐term effect of caesarean section on the gut microbial taxonomical profile and metabolic function of children at pre‐school age

Clinical and Translational Medicine, 2023
Chang Gao, Dan‐Tong Shao, Cheng‐Rui Wang, Ya‐Shu Kuang, Jin‐Hua Lu, Ding‐Yuan Zeng, Jian‐Rong He, Xiu Qiu   +7 more
doaj   +1 more source