Results 91 to 100 of about 43,437,062 (345)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The Hertfordshire Cohort Study: an overview [PDF]

F1000Research, 2019
The Hertfordshire Cohort Study is a nationally unique study of men and women born in the English county of Hertfordshire in the early part of the 20th century. Records that detail their health in infancy and childhood have been preserved, their sociodemographic, lifestyle, medical and biological attributes have been characterised in later life, and ...
Cyrus Cooper, Cyrus Cooper, Sian M. Robinson, S. J. Simmonds, Sarah Carter, Elaine M. Dennison, Holly E. Syddall   +6 more
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design.

American Journal of Epidemiology, 2018
Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to ...
H. Poustchi, S. Eghtesad, F. Kamangar, A. Etemadi, A. Keshtkar, A. Hekmatdoost, Z. Mohammadi, Z. Mahmoudi, Amaneh Shayanrad, F. Roozafzai, M. Sheikh, Alireza Jalaeikhoo, M. Somi, F. Mansour-Ghanaei, F. Najafi, E. Bahramali, A. Mehrparvar, A. Ansari-Moghaddam, A. Enayati, Ali Esmaeili Nadimi, A. Rezaianzadeh, N. Saki, Fateme Alipour, R. Kelishadi, A. Rahimi-Movaghar, N. Aminisani, P. Boffetta, R. Malekzadeh   +27 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Cohort Profile: The UK Women’s Cohort Study (UKWCS) [PDF]

International Journal of Epidemiology, 2015
Cohort Profile: The UK Women’s Cohort Study (UKWCS) Janet E Cade,* Victoria J Burley, Nisreen A Alwan, Jayne Hutchinson, Neil Hancock, Michelle A Morris, Diane E Threapleton and Darren C Greenwood School of Food Science and Nutrition, Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK, Department of Health ...
Cade, Janet E., Burley, Victoria J., Alwan, Nisreen A., Hutchinson, Jayne, Hancock, Neil, Morris, Michelle A., Threapleton, Diane E., Greenwood, Darren C.   +7 more
openaire   +5 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Association of antiviral prophylaxis and rituximab use with posttransplant lymphoproliferative disorders (PTLDs): A nationwide cohort study

American Journal of Transplantation, 2020
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT). Most PTLD cases are associated with Epstein–Barr virus (EBV) infection.
L. Walti, C. Mugglin, D. Sidler, Matteo Mombelli, O. Manuel, H. Hirsch, N. Khanna, N. Mueller, C. Berger, K. Boggian, C. Garzoni, D. Neofytos, C. van Delden, C. Hirzel, Swiss Transplant Cohort Study Stcs   +14 more
semanticscholar   +1 more source

Cohort Profile: The Limache, Chile, birth cohort study [PDF]

International Journal of Epidemiology, 2013
The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1232 participants born between 1974 and 1978 in the hospital of
Amigo, Hugo, Bustos, Patricia, Zumelzú, Elinor, Rona, Roberto J.   +3 more
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source