Results 131 to 140 of about 43,437,062 (345)

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

The Lancet, 2020
L. Verdoni, A. Mazza, A. Gervasoni, L. Martelli, M. Ruggeri, M. Ciuffreda, E. Bonanomi, L. D’Antiga   +7 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life [PDF]

, 1988
Alejandro Cravioto, Rosa Reyes, Roberto Ortega, G. Esteban Fernández, Raymundo Hernández, Dolores López   +5 more
openalex   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Increasing hepatitis C virus RNA levels in hemophiliacs: relationship to human immunodeficiency virus infection and liver disease. Multicenter Hemophilia Cohort Study [PDF]

, 1994
M. Elaine Eyster, MW Fried, AM Di Bisceglie, J. J. Goedert   +3 more
openalex   +3 more sources

Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study

Lancet Public Health, 2020
L. Nguyen, David A. Drew, M. Graham, A. Joshi, Chuan-Guo Guo, Wenjie Ma, Raaj S. Mehta, Erica T. Warner, Daniel R. Sikavi, Chun-Han Lo, Sohee Kwon, M. Song, L. Mucci, M. Stampfer, W. Willett, A. Eliassen, J. Hart, J. Chavarro, J. Rich-Edwards, R. Davies, J. Capdevila, KarlaA Lee, M. N. Lochlainn, Thomas Varsavsky, C. Sudre, M. Jorge Cardoso, J. Wolf, T. Spector, S. Ourselin, C. Steves, A. Chan   +30 more
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study

Lancet. Infectious Diseases (Print), 2020
Qifang Bi, Yongsheng Wu, S. Mei, Chenfei Ye, X. Zou, Zhen Zhang, Xiaojian Liu, Lan Wei, S. Truelove, Tong Zhang, W. Gao, Cong Cheng, Xiujuan Tang, Xiaoliang Wu, Yu Wu, B. Sun, Suli Huang, Yu Sun, Juncen Zhang, Ting Ma, J. Lessler, T. Feng   +21 more
semanticscholar   +1 more source

Pelvic inflammatory disease and the intrauterine device: findings in a large cohort study. [PDF]

, 1981
Martin Vessey, D Yeates, Rosemary Flavel, Klim McPherson   +3 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source