Results 131 to 140 of about 46,993,701 (406)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The FinnBrain multimodal neonatal template and atlas collection

Communications Biology
The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not.
Jetro J. Tuulari, Aylin Rosberg, Elmo P. Pulli, Niloofar Hashempour, Elena Ukharova, Kristian Lidauer, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K. Audah, Elena Vartiainen, Wajiha Bano, Ilkka Suuronen, Isabella L. C. Mariani Wigley, Vladimir S. Fonov, D. Louis Collins, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, John D. Lewis   +18 more
doaj   +1 more source

Organisational justice and health of employees: prospective cohort study [PDF]

, 2003
Aims: To examine the association between components of organisational justice (that is, justice of decision making procedures and interpersonal treatment) and health of employees.Methods: The Poisson regression analyses of recorded all-cause sickness ...
Elovainio, M, Ferrie, JE, Kivimaki, M, Vahtera, J   +3 more
core  

Prevention of osteoporotic refractures in regional Australia [PDF]

, 2017
Objective: Clinical guidelines recommend that patients who sustain a minimal trauma fracture (MTF) should receive a bone mineral density (BMD) scan and bisphosphonate (or equivalent) therapy if diagnosed with osteoporosis.
Davidson, E, Doyle, Z, Fielding, K, McGirr, J, Seal, A   +4 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The microbiota of the bilio-pancreatic system: A cohort, STROBE-compliant study [PDF]

, 2019
Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.
Agrusa A., D'arpa F., Di Carlo P., Fasciana T., Giammanco A., Gulotta G., Rodolico V., Sergi C., Serra N.   +8 more
core   +1 more source

Exploring the causal role of intimate partner violence and abuse on depressive symptoms in young adults: a population-based cohort study [PDF]

, 2022
Annie Herbert, Jon Heron, Maria Barnes, Christine Barter, Gene Feder, Khadija Meghrawi, Eszter Szilassy, Abigail Fraser, Laura D. Howe   +8 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Patient-reported outcomes of periacetabular osteotomy from the prospective ANCHOR cohort study [PDF]

, 2017
BACKGROUND: Current literature describing the periacetabular osteotomy (PAO) is mostly limited to retrospective case series. Larger, prospective cohort studies are needed to provide better clinical evidence regarding this procedure.
Amstutz, Beck, Bellamy, Biedermann, Clavien, Clohisy, Clohisy, Clohisy, Clohisy, Clohisy, Daniel J. Sucato, David A. Podeszwa, Dindo, Duncan, Ernest L. Sink, Ganz, Geneva Baca, Harris, Hartig-Andreasen, Ira Zaltz, Jack Baty, Jeffrey Ackerman, John C. Clohisy, Lequesne, Matheney, Matta, McKinley, Michael B. Millis, Murphy, Nepple, Nilsdotter, Ninomiya, Paul E. Beaulé, Perry L. Schoenecker, Peters, Rafael J. Sierra, Robert T. Trousdale, Robertson, Salter, Siebenrock, Sink, Sink, Steel, Steppacher, Steppacher, Sugano, Troelsen, Tönnis, Tönnis, Wiberg, Yasunaga, Young-Jo Kim, Zaltz, Ziebarth   +53 more
core   +2 more sources

Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study [PDF]

, 2021
Cheng Li, Yichen He, Jing-Jing Xu, Yu Wang, Han Liu, Chen-Chi Duan, Chao-Yi Shi, Lei Chen, Jie Wang, Jian‐Zhong Sheng, Hefeng Huang, Yanting Wu   +11 more
openalex   +1 more source