Results 51 to 60 of about 2,873,998 (272)

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity

BMC Medicine
Background It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring’s brain in a manner that confers ...
Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari   +9 more
doaj   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Artificial intelligence for diagnosing and predicting survival of patients with renal cell carcinoma: Retrospective multi-center study [PDF]

arXiv, 2023
Background: Clear cell renal cell carcinoma (ccRCC) is the most common renal-related tumor with high heterogeneity. There is still an urgent need for novel diagnostic and prognostic biomarkers for ccRCC. Methods: We proposed a weakly-supervised deep learning strategy using conventional histology of 1752 whole slide images from multiple centers.
arxiv  

Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland

Swiss Medical Weekly, 2018
BACKGROUND Post-transplant lymphoproliferative disorder (PTLD) is a potentially life-threatening complication of transplantation occurring in the setting of immunosuppression and oncogenic viral infections.
Raphael E. Steiner, Robert Kridel, Emiliano Giostra, Thomas A. McKee, Rita Achermann, Nicolas J. Mueller, Oriol Manuel, Michael Dickenmann, Macé M. Schuurmans, Laurence de Leval, Thomas Fehr, Marianne Tinguely, Isabelle Binet, Sergio Cogliatti, Eugenia Haralamvieva, Michael Koller, the Swiss Transplant Cohort Study (STCS), Pierre-Yves Dietrich   +17 more
doaj   +1 more source

Alexithymic Traits and Hair Cortisol Concentrations in Pregnant Women

Frontiers in Psychiatry, 2020
IntroductionAlexithymia, a personality construct characterized by difficulties in identifying and expressing emotions, and an externally oriented thinking style, has been associated with a number of stress-related disorders, and physiological markers of ...
Jani Kajanoja, Jani Kajanoja, Jani Kajanoja, Max Karukivi, Max Karukivi, Max Karukivi, Paula Mustonen, Paula Mustonen, Noora M. Scheinin, Noora M. Scheinin, Susanna Kortesluoma, Ana João Rodrigues, Hasse Karlsson, Hasse Karlsson, Linnea Karlsson, Linnea Karlsson, Linnea Karlsson   +16 more
doaj   +1 more source

Maternal Executive Functioning, Emotional Availability and Psychological Distress During Toddlerhood: A FinnBrain Birth Cohort Study

Frontiers in Psychology, 2021
Executive functioning (EF) is one of the building blocks in parental caregiving behavior, and contextual variables have been reported to moderate the link between EF and caregiving behavior.
Elisabeth Nordenswan, Elisabeth Nordenswan, Kirby Deater-Deckard, Mira Karrasch, Matti Laine, Eeva-Leena Kataja, Eeva Holmberg, Eeva Eskola, Hetti Hakanen, Hasse Karlsson, Hasse Karlsson, Hasse Karlsson, Linnea Karlsson, Linnea Karlsson, Linnea Karlsson, Riikka Korja, Riikka Korja   +16 more
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Maternal Pregnancy-Related Anxiety Is Associated With Sexually Dimorphic Alterations in Amygdala Volume in 4-Year-Old Children

Frontiers in Behavioral Neuroscience, 2019
Prenatal stress is associated with child behavioral outcomes increasing susceptibility for psychiatric disorders in later life. Altered fetal brain development might partly mediate this association, as some studies suggest.
Henriette Acosta, Jetro J. Tuulari, Jetro J. Tuulari, Jetro J. Tuulari, Noora M. Scheinin, Niloofar Hashempour, Olli Rajasilta, Tuomas I. Lavonius, Juho Pelto, Virva Saunavaara, Riitta Parkkola, Tuire Lähdesmäki, Linnea Karlsson, Linnea Karlsson, Hasse Karlsson, Hasse Karlsson   +15 more
doaj   +1 more source

Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study

Frontiers in Neurology, 2020
Background: Birth is a traumatic event with molding forces directed to the fetal skull, which may result in intracranial hemorrhages. However, the knowledge on prevalence and risk factors of incidental brain magnetic resonance imaging (MRI) findings in ...
Venla Kumpulainen, Satu J. Lehtola, Jetro J. Tuulari, Jetro J. Tuulari, Eero Silver, Anni Copeland, Riikka Korja, Riikka Korja, Hasse Karlsson, Hasse Karlsson, Hasse Karlsson, Linnea Karlsson, Linnea Karlsson, Linnea Karlsson, Harri Merisaari, Harri Merisaari, Harri Merisaari, Riitta Parkkola, Riitta Parkkola, Jani Saunavaara, Tuire Lähdesmäki, Tuire Lähdesmäki, Noora M. Scheinin, Noora M. Scheinin   +23 more
doaj   +1 more source

Factors influencing treatment status of syphilis among pregnant women: a retrospective cohort study in Guangzhou, China

International Journal for Equity in Health, 2023
Background Many syphilis infected pregnant women do not receive treatment, representing a major missed opportunity to reduce the risk of syphilis-related adverse pregnancy outcomes.
Huihui Liu, Niannian Chen, Weiming Tang, Songying Shen, Jia Yu, Huiyun Xiao, Xingwen Zou, Jianrong He, Joseph D. Tucker, Xiu Qiu   +9 more
doaj   +1 more source