Results 101 to 110 of about 790,002 (307)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Comparison between coil and hook-wire localization before video-assisted thoracoscopic surgery for lung nodules: a systematic review and meta-analysis

Videosurgery and Other Miniinvasive Techniques, 2022
Jian-Li Wang, Feng-Fei Xia, Ai-Hong Dong, Yun Lu   +3 more
doaj   +1 more source

Effects of (Ti, Mo)C precipitation on the microstructure, impact toughness, and sulfide stress corrosion cracking resistance of linepipe steels

Journal of Materials Research and Technology
There is a growing need to develop high-performance linepipes owing to the accelerated resource depletion attributable to the increasing interest in mining in extreme environments.
Seoyoon Gong, Seungon Lim, Kyu-Tae Kim, Yong-Jae Yu, S.E. Shin   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Development of a U.S./U.K. Collaborative Online International Learning (COIL) partnership for undergraduate education in public health

Journal of Virtual Exchange
Preparing future public health (U.S.) or health and social care (U.K.) professionals for international settings is imperative in today’s higher education landscape.
Amy Versnik Nowak, Marzell Gray, Damilola Omodara, Linda Gibson   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The new Magnetic Measurement System at the Advanced Photon Source [PDF]

, 2001
A new system for precise measurements of the field integrals and multipole components of the APS magnetic insertion devices is described. A stretched coil is used to measure magnetic field characteristics. The hardware includes a number of servomotors to
Deriy, B., Eidelman, Yu., Makarov, O., Vasserman, I.   +3 more
core   +1 more source

Descending aorta to right atrial fistula: Transcatheter embolization of a very rare anomaly with coils

Clinical Case Reports
Key Clinical Message Descending aorta to right atrial (RA) fistula is a rare and distinct clinical entity mimicking patent ductus arteriosus (PDA) and it may lead to rapid development of pulmonary vascular disease.
Stefanos Despotopoulos, Sotiria Apostolopoulou, George Vagenakis, Meletios Kanakis, George Samanidis, Panagiotis Zachos, Anastasios Chatziantoniou, John Papagiannis, Spyridon Rammos, Alexandros Tsoutsinos   +9 more
doaj   +1 more source

Analysis of heat transfer in a helically coiled cooler of a mechatronic sample conditioning system

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
A mechatronic sample conditioning system requires a high degree of process automation. Special attention is to be paid to the cooling of a sample and maintaining its temperature and pressure.
A. G. Gimadiev, A. V. Utkin
doaj   +1 more source