Results 81 to 90 of about 1,097,336 (352)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Structural determinants of coiled coil mechanics
Physical Chemistry Chemical Physics, 2019 In shear geometry, the sequence–structure–mechanics relationship of rationally designed coiled coil heterodimers is determined by the helix propensity of the individual helices and the packing density at the hydrophobic core.
Patricia Lopez-Garcia +5 more
openaire +4 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
The Observed Linearity and Detection Response of Magnetic Fluid Concentration Magnetometry - A Theoretical and Experimental Description [PDF]
, 2013 The response of a Scanning Column Magnetometer (SCM) used to measure concentration profiles of columns of magnetic dispersions has been investigated experimentally and theoretically.
Bissell, Philip, Mercer, Tim
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Brain and Behavior, 2021 Background A long debate has been going on in the clinical effectiveness to determine whether surgical clipping or coiling more favorable for oculomotor nerve palsy (ONP) caused by PcomAA. We aimed to perform a study, focusing on the effectiveness of ONP
Zidong Wang, Xiaokui Kang, Qingdong Wang
doaj +1 more source
The Golgin Family of Coiled-Coil Tethering Proteins
Front. Cell Dev. Biol., 2016 The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an evolutionary conserved function.
Tomasz M. Witkos, M. Lowe
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Analysis of coil slumping [PDF]
, 2009 Steel strip is usually stored as a coil, which will slump to some degree after the removal of the mandrel. More often than not, the amount of slumping is so minor that it is assumed not to have occurred.
Anderssen, Bob +3 more
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source