Results 61 to 70 of about 22,504 (264)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Coil‐by‐coil image reconstruction with SMASH [PDF]

Magnetic Resonance in Medicine, 2001
AbstractThe SiMultaneous Acquisition of Spatial Harmonics (SMASH) technique uses linear combinations of undersampled datasets from the component coils of an RF coil array to reconstruct fully sampled composite datasets in reduced imaging times. In previously reported implementations, SMASH reconstructions were designed to reproduce the images that ...
C A, McKenzie, M A, Ohliger, E N, Yeh, M D, Price, D K, Sodickson   +4 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coiled Basketry [PDF]

Science, 1902
n ...
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mid-term safety and efficacy in small intracranial aneurysm coiling: results from TARGET® nano prospective independent core lab adjudicated multicenter registry

Frontiers in Neurology
BackgroundThe primary objective is to evaluate the safety and effectiveness of Stryker second generation Target® Nano Coils in the treatment of ruptured and unruptured small (<7 mm) intracranial aneurysms.MethodsThe TARGET Registry is a prospective ...
Yazan Ashouri, Alexandra R. Paul, Ajit Puri, Nicholas Liaw, Aniel Majjhoo, Aniel Majjhoo, Asif Taqi, Ansaar Rai, Aamir Badruddin, Amer Alshekhlee, Bharath Naravetla, Bharath Naravetla, Mahmoud Rayes, Matthew Lawson, Batool Al Masaid, Claire Langerford, Qaisar Shah, Karen Beaty, Eugene Lin, Tanner Gray-Duvall, Jasmine Olvany, Hannah Slight, Varun Chaubal, Saif Bushnaq, Benedict Tan, Mohammad Al Majali, Lucas Elijovich, Peter Sunenshine, Osama O. Zaidat   +28 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A High-grade Aneurysmal Subarachnoid Hemorrhage in the Peripartum Period

Journal of Emergencies, Trauma and Shock
Aneurysmal subarachnoid hemorrhage (aSAH) is a rare but devastating complication with increased morbidity and mortality. It is still unclear whether the incidence is increased during pregnancy and in the peripartum period.
Nissar Shaikh, Adnan Saadeddin, Firdos Ummunnisa, Umm-e Amara, Abdulnasser Thabet, Seema Nahid   +5 more
doaj   +1 more source