Results 61 to 70 of about 29,669 (308)
Feasibility, Safety, and Efficacy of Endovascular . Surgical Treatment of Unruptured Multi-Sac Intracranial Aneurysms in a Single-Center Retrospective Series [PDF]
NeurointerventionPurpose Multi-sac aneurysms (MSAs) are not uncommon, but studies on their management are scarce. This study aims to evaluate and compare the feasibility, safety, and efficacy of MSAs treated with either clipping or coiling after interdisciplinary case ...
Lukas Goertz +10 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural determinants of coiled coil mechanics
Physical Chemistry Chemical Physics, 2019 In shear geometry, the sequence–structure–mechanics relationship of rationally designed coiled coil heterodimers is determined by the helix propensity of the individual helices and the packing density at the hydrophobic core.
Patricia Lopez-Garcia +5 more
openaire +4 more sources
Sliding Mechanism at a Coiled-Coil Interface [PDF]
Biophysical Journal, 2019 The α-helical coiled coil (CC) is a common protein motif that because of the simplicity of its sequence/structure relationship, it has been studied extensively to address fundamental questions in protein science as well as to develop strategies for designing protein with novel architectures.
David, Gomez +2 more
openaire +2 more sources
Analysis on Telescoped Coil Defect of Hot Galvanized Strip and Preventing Measures
Teshugang, 2011 According to analysis on telescoped coil produced during coiling process of hot galvanized strip, it is obtained that the unmatched coiling tension and the slip of mandrel in sleeve are main causes to bring about telescoped coil defect.
岑耀东
doaj
Scientific Reports, 2022 Endovascular coiling represents the standard treatment for basilar tip aneurysms. Some of these aneurysms are not amenable to conventional coiling due to a complex aneurysm geometry, hence, novel devices such as the Woven Endobridge (WEB) have been ...
Erkan Celik +8 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Structural specificity in coiled-coil interactions [PDF]
Current Opinion in Structural Biology, 2008 Coiled coils have a rich history in the field of protein design and engineering. Novel structures, such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area.
Gevorg, Grigoryan, Amy E, Keating
openaire +2 more sources
Conformational control in a photoswitchable coiled coil
Chemical Communications, 2021 Reversible conformational control is demonstrated in helical coiled coils.
Justin M. Torner, Paramjit S. Arora
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source