Results 41 to 50 of about 22,504 (264)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Comparison of long-term clinical outcome after endovascular versus neurosurgical treatment of ruptured intracranial anterior circulation aneurysms: A single-centre experience

Brain and Spine
Introduction: In patients with anterior circulation aneurysmal Subarachnoid Haemorrhage (aSAH), endovascular coiling is currently practiced more frequently than neurosurgical clipping.
Alexander Hamming, Jeroen van Dijck, Ranjit Singh, Wilco Peul, Wouter Moojen   +4 more
doaj   +1 more source

Tubridge flow diverter alone vs. Tubridge flow diverter and coils for the treatment of intracranial aneurysms: A propensity score matching analysis

Frontiers in Neurology, 2022
BackgroundThe study was designed to assess the clinical performance of a tubridge flow diverter (TFD) in the treatment of intracranial aneurysms and to compare the efficacy and safety between intracranial aneurysms treated with TFD alone and TFD combined
Min Shi, Yu Feng, Cheng-Da Zhang, Qing-Wen Tang, Ze-Jin Li, Wen-Yuan Zhao, Ting-Bao Zhang   +6 more
doaj   +1 more source

Molecular basis of coiled-coil formation [PDF]

Proceedings of the National Academy of Sciences, 2007
Coiled coils have attracted considerable interest as design templates in a wide range of applications. Successful coiled-coil design strategies therefore require a detailed understanding of coiled-coil folding. One common feature shared by coiled coils is the presence of a short autonomous helical folding unit, termed “trigger sequence,” that is ...
Steinmetz, Michel O., Jelesarov, Ilian, Matousek, William M., Honnappa, Srinivas, Jahnke, Wolfgang, Missimer, John H., Frank, Sabine, Alexandrescu, Andrei T., Kammerer, Richard A.   +8 more
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Different antiplatelet regimens for stenting versus coiling for acutely-ruptured cerebral aneurysms

Scientific Reports
To investigate the safety, efficacy and risk factors for complications of stenting with optional coiling versus coiling alone for acutely ruptured cerebral aneurysms (ARCAs) using different antiplatelet schemes, 2021 patients were prospectively enrolled ...
Li Li, Qing-Hai Huang, Qiu-Ji Shao, Kai-Tao Chang, Qian-Qian Zhang, Liang-Fu Zhu, Jian-Min Liu, Tian-Xiao Li, Bu-Lang Gao   +8 more
doaj   +1 more source

Anterior Communicating Artery Aneurysms: Anatomical Considerations and Microsurgical Strategies

Frontiers in Neurology, 2020
Anterior communicating artery aneurysms account for 23–40% of ruptured intracranial aneurysms and 12–15% of unruptured aneurysms and are the most common intracranial ruptured or unruptured aneurysms.
Junhui Chen, Junhui Chen, Mingchang Li, Xun Zhu, Yan Chen, Chunlei Zhang, Wenwen Shi, Qianxue Chen, Yuhai Wang   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis on Telescoped Coil Defect of Hot Galvanized Strip and Preventing Measures

Teshugang, 2011
According to analysis on telescoped coil produced during coiling process of hot galvanized strip, it is obtained that the unmatched coiling tension and the slip of mandrel in sleeve are main causes to bring about telescoped coil defect.
岑耀东
doaj