Results 41 to 50 of about 29,669 (308)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

TCMacro: A Simple and Robust ImageJ-Based Method for Automated Measurement of Tail Coiling Activity in Zebrafish

Biomolecules, 2021
Tail coiling is a reflection response in fish embryos that can be used as a model for neurotoxic analysis. The previous method to analyze fish tail coiling is largely based on third-party software.
Kevin Adi Kurnia, Fiorency Santoso, Bonifasius Putera Sampurna, Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Chung-Der Hsiao   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Liquid rope coiling on a solid surface.

, 2004
We present an experimental study of the coiling instability of a liquid "rope" falling on a solid surface. Coiling can occur in three different regimes--viscous, gravitational, or inertial--depending on the fluid viscosity and density, the fall height ...
Ribe, NM, Golestanian, R. ; https://orcid.org/, Golestanian, R, Ribe, N., Habibi, M, Bonn, D, Maleki, M., Golestanian, Ramin, Habibi, M., Bonn, D., Ribe, N.M., Maleki, M, Bonn, Daniel, Golestanian, R.   +13 more
core   +1 more source

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins [PDF]

Acta Crystallographica Section D Biological Crystallography, 2015
GemC1, together with Idas and Geminin, an important regulator of DNA-replication licensing and differentiation decisions, constitute a superfamily sharing a homologous central coiled-coil domain. To better understand this family of proteins, the crystal structure of a GemC1 coiled-coil domain variant engineered for better solubility was determined to 2.
Caillat C., Fish A., Pefani D.E., Taraviras S., Lygerou Z., Perrakis A.   +5 more
openaire   +3 more sources

Anterior Communicating Artery Aneurysms: Anatomical Considerations and Microsurgical Strategies

Frontiers in Neurology, 2020
Anterior communicating artery aneurysms account for 23–40% of ruptured intracranial aneurysms and 12–15% of unruptured aneurysms and are the most common intracranial ruptured or unruptured aneurysms.
Junhui Chen, Junhui Chen, Mingchang Li, Xun Zhu, Yan Chen, Chunlei Zhang, Wenwen Shi, Qianxue Chen, Yuhai Wang   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A coiling robot for elevator compensation chain

, 2016
Purpose - The purpose of this paper is to develop a coiling robot in the production of coated elevator compensation chains to replace the manual coiling operations and improve the quality of compensation chains.
Shi, Xianchuan, Gao, Liang, Qian, Lei, Cheng, Mingya, Jiang, Kyle   +4 more
core   +1 more source

Growth and instability of a laminar plume in a strongly stratified environment [PDF]

, 2011
Experimental studies of laminar plumes descending under gravity into stably stratified environments have shown the existence of a critical injection velocity beyond which the plume exhibits a bifurcation to a coiling instability in three dimensions or a ...
Cossu, Carlo, Goldstein, Raymond E., Pesci, A. I., Goldstein, R. E., R. E. GOLDSTEIN, Pesci, Adriana I., C. COSSU, Caulfield, C. P., Cossu, C., Lombardi, M., A. I. PESCI, M. LOMBARDI, Caulfield, Colm-Cille P., C. P. CAULFIELD, Lombardi, Matteo   +14 more
core   +1 more source

A new twist to coiled coil

FEBS Letters, 2012
Spectrin repeats have been largely considered as passive linkers or spacers with little functional role other than to convey flexibility to a protein. Whilst this is undoubtedly part of their function, it is by no means all. Whilst the overt structure of all spectrin repeats is a simple triple‐helical coiled coil, the linkages between repeats and the ...
Le Rumeur, Elisabeth, Hubert, Jean-François, Winder, Steve   +2 more
openaire   +2 more sources