Results 81 to 90 of about 312,905 (302)
Predicting oligomerization states of coiled coils [PDF]
Protein Science, 1995 AbstractAn algorithm based on the profile method was developed that faithfully distinguishes between the amino acid sequences of dimeric and trimeric coiled coils. Normalized sequence profiles derived from nonhomologous, two‐and three‐stranded, coiled‐coil sequences with unambiguous registers were used to assign dimer and trimer propensities to test ...
D N, Woolfson, T, Alber
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Coil‐by‐coil image reconstruction with SMASH [PDF]
Magnetic Resonance in Medicine, 2001 AbstractThe SiMultaneous Acquisition of Spatial Harmonics (SMASH) technique uses linear combinations of undersampled datasets from the component coils of an RF coil array to reconstruct fully sampled composite datasets in reduced imaging times. In previously reported implementations, SMASH reconstructions were designed to reproduce the images that ...
C A, McKenzie +4 more
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
International Journal of COPD, 2018 Konstantina Kontogianni,1,2 Kanoe Russell,3 Ralf Eberhardt,1,2 Maren Schuhmann,1,2 Claus Peter Heussel,2,4 Susan Wood,3 Felix JF Herth,1,2 Daniela Gompelmann1,2 1Department of Pulmonology and Respiratory Care Medicine, Thoraxklinik at the ...
Kontogianni K +7 more
doaj
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Ultra-fast moving coil actuator for power switches in medium-voltage grids
The Journal of Engineering, 2019 The need for faster power switches leads to the following question: Which technical actuation principle has the highest acceleration potential? This study describes the investigation of electrodynamic moving coil (voice coil) actuators.
Tom Stroehla +5 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Design of electromagnetic sensor for metal wear particle detection in oil
The Journal of Engineering, 2019 Wear is one of the common faults in the mechanical transmission system. Detection of wear particles in lubricating oil can detect and evaluate the wear degree of mechanical equipment.
Yunbo Zuo, Yuhai Gu, Yanhai Zhang
doaj +1 more source