Results 71 to 80 of about 91,233 (268)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Single-phase grouding fault analysis and control scheme of transformerless flexible multistate switch

The Journal of Engineering, 2019
The compact design is suitable for the urban areas with intensive loads. The flexible multistate switch (FMS) can effectively reduce the footprint by removing transformers, which is the development trend of the flexible AC distribution equipment.
Feng Xu, Yi Lu, Xiaohua Xuan, Haihong Yu, Peng Qiu, Daozhuo Jiang   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Studies on the Electro-Impulse De-Icing System of Aircraft

Aerospace, 2019
In order to solve the accidents caused by aircraft icing, electro-impulse de-icing technology was studied through numerical simulation and experimental verification.
Xingliang Jiang, Yangyang Wang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Transient Current Sharing Method for Parallel SiC MOSFETs Based on Gate‐Source Voltage Difference

IET Power Electronics
In the design of high‐power converters, significant parameter dispersion among different SiC MOSFET devices can cause substantial current differences during switching when devices are directly paralleled.
Hao Pan, Haichuan Zhou, Zhen Wang, Yufeng Zhao, Limin Jia   +4 more
doaj   +1 more source

Head-to-Head Comparison of Flow Reduction between Fibered and Non-Fibered Pushable Coils [PDF]

Neurointervention
Purpose To compare the embolization effects of a non-fibered pushable coil with a conventional fibered pushable coil in an in vitro bench-top experiment.
Jong-Tae Yoon, Boseong Kwon, Joon Ho Choi, Sun Moon Hwang, Mihyeon Kim, Sungbin Hwang, Yunsun Song, Deok Hee Lee   +7 more
doaj   +1 more source

TO COIL OR NOT TO COIL

Journal of the American College of Cardiology, 2021
Konstantinos Voudris, Christina Anderson, Anupama Rao, Hussam Suradi, Stuart Chen   +4 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Solving coiled-coil protein structures [PDF]

IUCrJ, 2015
The successful approach to solving crystal structures of coiled-coil proteins with the program AMPLE is discussed.
openaire   +3 more sources