Results 41 to 50 of about 33,542 (293)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Anti-periodic solution for fuzzy Cohen–Grossberg neural networks with time-varying and distributed delays

Nonlinear Analysis, 2015
In this paper, by using a continuation theorem of coincidence degree theory and a differential inequality, we establish some sufficient conditions ensuring the existence and global exponential stability of anti-periodic solutions for a class of fuzzy ...
Yongkun Li, Li Yang, Wanqin Wu
doaj   +1 more source

Existence and uniqueness of anti-periodic solutions for a class of nonlinear n-th order functional differential equations [PDF]

Opuscula Mathematica, 2011
In this paper, we use the method of coincide degree theory to establish new results on the existence and uniqueness of anti-periodic solutions for a class of nonlinear \(n\)-th order functional differential equations of the form \[x^{(n)}(t)=F(t, x_t, x^{
Ling Liu, Yongkun Li
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Existence of solutions to fractional differential equations with multi-point boundary conditions at resonance in Hilbert spaces

Electronic Journal of Differential Equations, 2016
This article is devoted to investigating the existence of solutions to fractional multi-point boundary-value problems at resonance in a Hilbert space.
Hua-Cheng Zhou, Fu-Dong Ge, Chun-Hai Kou
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

轮边减速器行星齿轮传动系统动态特性研究

Jixie chuandong, 2014
For automobile wheel planetary gear system noise and vibration problems in the process of moving due to the deterioration caused by the support conditions,considering the concept of displacement deformation bearing operation,based on the introduction of ...
刘家伦
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Solvability of second-order boundary-value problems at resonance involving integral conditions

Electronic Journal of Differential Equations, 2012
This article concerns the second-order differential equation with integral boundary conditions $$displaylines{ x''(t)=f(t,x(t),x'(t)),quad tin (0,1),cr x(0)=int_0^1x(s)dalpha(s),quad x(1)=int_0^1x(s)deta(s).
Yujun Cui
doaj