Results 51 to 60 of about 36,323 (288)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Lefschetz coincidence theory for maps between spaces of different dimensions [PDF]
, 2001 For a given pair of maps f,g:X→M from an arbitrary topological space to an n-manifold, the Lefschetz homomorphism is a certain graded homomorphism Λfg:H(X)→H(M) of degree (−n).
Saveliev, Peter
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Electronic Journal of Differential Equations, 2016 This article is devoted to investigating the existence of solutions to fractional multi-point boundary-value problems at resonance in a Hilbert space.
Hua-Cheng Zhou, Fu-Dong Ge, Chun-Hai Kou
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Nonlinear Analysis, 2015 In this paper, by using a continuation theorem of coincidence degree theory and a differential inequality, we establish some sufficient conditions ensuring the existence and global exponential stability of anti-periodic solutions for a class of fuzzy ...
Yongkun Li, Li Yang, Wanqin Wu
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
New Quasi-Coincidence Point Polynomial Problems [PDF]
, 2013 Let F:ℝ×ℝ→ℝ be a real-valued polynomial function of the form F(x,y)=as(x)ys+as-1(x)ys-1+⋯+a0(x), where the degree s of y in F(x,y) is greater than or equal to 1.
Hang-Chin Lai, Yi-Chou Chen
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Study of a class of arbitrary order differential equations by a coincidence degree method [PDF]
Boundary Value Problems, 2017 في هذه المخطوطة، نقوم بالتحقيق في بعض الشروط المناسبة التي تضمن وجود حل واحد على الأقل لفئة من المعادلات التفاضلية بالترتيب الكسري (FDEs) المقدمة من $$\ textstyle\begin{cases} - {}^{ C}\ mathbf{D }^{ q} z(t )=\ theta (t,z(t)); \quad t\in \mathfrak{J }=[ 0,1], q\in (1, 2], \\ z(t)\vert _{ t=0 }=\ phi (z),\qquad z(1 )=\ delta {}^{ C}\ mathbf{D }^{ p} z (\
Nigar Ali +4 more
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Parity and generalized multiplicity [PDF]
, 1991 Assuming that X and Y are Banach spaces and that T is a path of linear Fredholm operators with invertible endpoints, in [F-Pl] we defined a homotopy invariant "the parity of T .
Fitzpatrickp. +2 more
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