Results 91 to 100 of about 357,854 (283)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Coupled Coincidence Points of Mappings in Ordered Partial Metric Spaces

Abstract and Applied Analysis, 2012
New coupled coincidence point and coupled fixed point results in ordered partial metric spaces under the contractive conditions of Geraghty, Rakotch, and Branciari types are obtained. Examples show that these results are distinct from the known ones.
Zorana Golubović, Zoran Kadelburg, Stojan Radenović   +2 more
doaj   +1 more source

Existence of a common solution for a system of nonlinear integral equations via fixed point methods in b-metric spaces

Open Mathematics, 2016
In this paper we introduce a property and use this property to prove some common fixed point theorems in b-metric space. We also give some fixed point results on b-metric spaces endowed with an arbitrary binary relation which can be regarded as ...
Yamaod Oratai, Sintunavarat Wutiphol, Je Cho Yeol   +2 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

On coincidence and common fixed points of nearly densifying mappings

International Journal of Mathematics and Mathematical Sciences, 2000
Coincidence and common fixed point theorems for certain new classes of nearly densifying mappings are established. Our results extend, improve, and unify a lot of previously known theorems.
Zeqing Liu, Jeong Sheok Ume
doaj   +1 more source

Non-Expansive Multi-Valued Mappings and Convexity in Fuzzy Metric Space [PDF]

Sahand Communications in Mathematical Analysis
In this article, we delve into the concept of convexity within fuzzy metric spaces and delve into their structural characteristics. We present several theorems concerning the existence of coincidence points in fuzzy convex metric spaces.
Mohammad Rashid
doaj   +1 more source

Existence of Equilibrium in Minimax Inequalities, Saddle, Points, Fixed Points, and Games without Convexity Sets [PDF]

minimax inequality, saddle points, fixed points, coincidence points, discontinuity, non-quasiconcavity, non-convexity, and non ...
Rabia Nessah, Tarik Tazdait
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Highly deformed $^{40}$Ca configurations in $^{28}$Si + $^{12}$C

, 2002
The possible occurrence of highly deformed configurations in the $^{40}$Ca di-nuclear system formed in the $^{28}$Si + $^{12}$C reaction is investigated by analyzing the spectra of emitted light charged particles.
A. Gavron, A. Hachem, A. K. Dummer, A. Szanto de Toledo, A.J. Sierk, B. Fornal, B. Fornal, B. Fornal, B. Fornal, B. Shivakumar, B.A. Harmon, B.A. Harmon, C. Beck, C. Beck, C. Beck, C. Beck, C. Bhattacharya, C. Bhattacharya, C. Bhattacharya, C. Bhattacharya, C. Enaux, C.E. Svensson, C.E. Svensson, C.E. Svensson, C.M. Perey, D. Bandyopadhyay, D. Bandyopadhyay, D. Mahboub, D. Pocanic, D. Rudolph, D. Rudolph, D. Shapira, D. Shapira, D. Wilmore, D.K. Agnihotri, E. Ideguchi, E. Martin, E.W. MacDonald, F. Ajzenberg-Selove, F. Haas, F. Pühlhofer, F.G. Perey, G. La Rana, G. La Rana, G. Royer, G. Viesti, H. Morgenstern, I.M. Govil, I.M. Govil, I.M. Govil, I.M. Govil, J. Barrette, J. Töke, J.R. Huizenga, J.R. Huizenga, K. Eddahbi, K.T. Lesko, M. Blann, M. Kildir, M. Rousseau, M.F. Vineyard, N. Alamanos, N. Arena, N. Arena, O. Dorvaux, O. Stezowski, P. Jänker, P. Papka, R. M. Freeman, R. Nouicer, R. Nouicer, R. Ost, R. Ost, R.J. Charity, R.K. Choudhury, S. Cohen, S. Gary, S. J. Sanders, S. Shlomo, S. Szilner, S. Thummerer, S. Thummerer, S.J. Sanders, T. Matsuse, V. Rauch, W. Dilg, W.D. Myers, Y. Nagashima, Z. Majka   +88 more
core   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source