Results 51 to 60 of about 37,867 (284)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Stability theorems for estimating the distance to a set of coincidence points

open access: yes, 2020
Coincidence points of two set-valued mappings of metric spaces are analyzed. Uniform estimates are obtained for the distance to the set of coincidence points and to the set of intersections of the graphs of two set-valued mappings.
Zhukovskiy S.E.   +2 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Topological Transversality Coincidence Theory for Multivalued Maps with Selections in a Given Class

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2021
This paper presents the topological transversality coincidence theorem for general multivalued maps who have selections in a given class of maps.
O’Regan Donal
doaj   +1 more source

Some results on fixed and coincidence points for pairs of maps in metric spaces [PDF]

open access: yes, 1993
Following ideas of Dugundji and Granas, some general results are established on the existence of fixed and coincidence points for a pair of maps on metric spaces.
Rodríguez Montes, Jaime
core  

Some results on coincidence points [PDF]

open access: yesBulletin of the Australian Mathematical Society, 1999
In this paper we prove some coincidence point theorems for nonself single-valued and multivalued maps satisfying a nonexpansive condition. These extend fixed point theorems for multivalued maps of a number of authors.
Latif, Abdul, Tweddle, Ian
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A generalized coincidence point index

open access: yesApplied General Topology, 2005
The authors acknowledge the support of A.N.D.R.U., (Contract No 03/06 Code CU 19905) and M.E.R.S., (Project No B*2501/04/04), Laboratory M.M.E.R.E.
Benkafadar, N.M., Benkara-Mostefa, M.C.
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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