Results 101 to 110 of about 4,117 (196)

Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging [PDF]

application/pdfChronic ultraviolet （UV） radiation results in photoaged skin characterized by deep wrinkle formation. Recent studies suggest that diminishment of anchoring fi brils（ AF）, stabilizing the association of the basement membrane to the ...
Yamaguchi, Masanori, Igarashi, Manami, Kojima, Kaoru, Kon, Atsushi   +3 more
core   +1 more source

Integrative multi-omics and causal inference unveil novel therapeutic targets for primary sclerosing cholangitis and its genetic comorbidity with inflammatory bowel disease

npj Gut and Liver
Primary sclerosing cholangitis (PSC), a progressive liver disease with limited treatment options, exhibits frequent comorbidity with inflammatory bowel disease (IBD), yet shared therapeutic targets remain unexplored.
Wanzhe Liao, Haobin Zhou, Zhuofeng Wen, Weixuan Liang, Chongde Pan, Zhiyi Zhou, Jingzhang Sun, Chang Liu, Xiangdong Zhou, Qi Li, Naijun Yuan, Chuiguo Huang   +11 more
doaj   +1 more source

COL7A1 Gene [PDF]

, 2020
openaire   +1 more source

MUC16 and COL7A1 in ECM Remodeling in Lung Adenocarcinoma Metastasis

Lung adenocarcinoma (LUAD) remains one of the deadliest cancers globally, mainly due to its aggressive metastatic potential. Emerging evidence implicates extracellular matrix (ECM) remodeling as a critical driver of tumor progression.
Castillo Daura, Daniela
core  

COL7A1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Highly efficient CRISPR/Cas9‐mediated exon skipping for recessive dystrophic epidermolysis bullosa

Bioengineering & Translational Medicine
Gene therapy based on the CRISPR/Cas9 system has emerged as a promising strategy for treating the monogenic fragile skin disorder recessive dystrophic epidermolysis bullosa (RDEB).
Alex du Rand, John Hunt, Christopher Samson, Evert Loef, Chloe Malhi, Sarah Meidinger, Chun‐Jen Jennifer Chen, Ashley Nutsford, John Taylor, Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard   +12 more
doaj   +1 more source

COL7A1 wt Allele [PDF]

, 2020
openaire   +1 more source

185 CRISPR/Cas9 mediated gene correction of COL7A1 [PDF]

Journal of Investigative Dermatology, 2017
S. Hainzl, P. Peking, T. Kocher, E.M. Murauer, F. Larcher, M del Río, B.G. Duarte, M. Steiner, A. Klausegger, J.W. Bauer, J. Reichelt, U. Koller   +11 more
openaire   +1 more source

Dominant dystrophic epidermolysis bullosa (Pasini) caused by a novel glycine substitution mutation in the type VII collagen gene (COL7A1)

, 1999
A 12 y old girl with the albopapuloid variant (Pasini) of dominant dystrophic epidermolysis bullosa is studied. The albopapuloid lesions developed within the first year of life, contained milia and were associated with pruritus. Mutation detection of the
Pulkkinen, L, Uitto, J, Moreno, G, Oranje, AP, Rouan, F, Jonkman, MF, Oranje, Arnold   +6 more
core   +1 more source

COL7A1 Exon 73 Mutation [PDF]

, 2020
openaire   +1 more source