Generation of rabbit polyclonal human and murine collagen VII monospecific antibodies: A useful tool for dystrophic epidermolysis bullosa therapy studies [PDF]
Matrix Biology Plus, 2019 High conservation of extracellular matrix proteins often makes the generation of potent species-specific antibodies challenging. For collagen VII there is a particular preclinical interest in the ability to discriminate between human and murine collagen ...
Olivier Bornert +6 more
doaj +2 more sources
Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII [PDF]
Matrix Biology Plus, 2021 Astacin-like proteinases (ALPs) are regulators of tissue and extracellular matrix (ECM) homeostasis. They convey this property through their ability to convert ECM protein pro-forms to functional mature proteins and by regulating the bioavailability of ...
Daniel Kruppa +6 more
doaj +2 more sources
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo [PDF]
Matrix Biology, 2022 John A Mcgrath +2 more
exaly +2 more sources
Global remodelling of cellular microenvironment due to loss of collagen VII [PDF]
Molecular Systems Biology, 2013 The mammalian cellular microenvironment is shaped by soluble factors and structural components, the extracellular matrix, providing physical support, regulating adhesion and signalling.
Victoria Küttner +7 more
doaj +2 more sources
Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes [PDF]
Cell Transplantation, 2019 Dorothy M Supp +2 more
exaly +2 more sources
Dystrophic epidermolysis bullosa: genotype-phenotype correlations [PDF]
Vestnik Dermatologii i Venerologii, 2023 Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene. The disease characterized by clinical heterogeneity. To date, scientific findings allow to evaluate correlations between the severity of clinical manifestations and genetic ...
Alexey A. Kubanov +2 more
doaj +1 more source
Acta Dermato-Venereologica, 2021 Epidermolysis bullosa acquisita is a pemphigoid disease characterized by autoantibodies against type VII collagen. This study compared the sensitivity and specificity of 6 diagnostic assays: type VII collagen non-collagenous domains enzyme-linked ...
Maike M. Holtsche +9 more
doaj +1 more source
Blister‐inducing antibodies target multiple epitopes on collagen VII in mice [PDF]
Journal of Cellular and Molecular Medicine, 2014 Emilia Licarete, Cassian Sitaru
exaly +2 more sources
A novel deletion and two recurrent substitutions on type VII collagen gene in seven Iranian patients with epidermolysis bullosa [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Epidermolysis bullosa is one of the most important series of mechano-bullous heritable skin disorders which is categorized into four major types according to the layer that bullae forms within basement membrane zone.
Armita Kakavand Hamidi +3 more
doaj +1 more source
CRISPR/Cas9-Mediated Generation of COL7A1-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa [PDF]
Cell Journal, 2023 Objective: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility and ultimately lethal blisteringdisease caused by mutations in the COL7A1 gene which is responsible for coding type VII collagen.
Farzad Alipour +5 more
doaj +1 more source