Generation of rabbit polyclonal human and murine collagen VII monospecific antibodies: A useful tool for dystrophic epidermolysis bullosa therapy studies [PDF]
Matrix Biology Plus, 2019 High conservation of extracellular matrix proteins often makes the generation of potent species-specific antibodies challenging. For collagen VII there is a particular preclinical interest in the ability to discriminate between human and murine collagen ...
Olivier Bornert +6 more
doaj +2 more sources
Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII [PDF]
Matrix Biology Plus, 2021 Astacin-like proteinases (ALPs) are regulators of tissue and extracellular matrix (ECM) homeostasis. They convey this property through their ability to convert ECM protein pro-forms to functional mature proteins and by regulating the bioavailability of ...
Daniel Kruppa +6 more
doaj +2 more sources
Recombinant humanized type VII collagen for skin repair and regeneration: prospects for reconstructing the dermal-epidermal junction [PDF]
Frontiers in MedicineType VII collagen (Col VII) is a key component of the anchoring fibrils at the dermal-epidermal junction (DEJ). It plays a crucial role in maintaining stable adhesion between the epidermis and dermis, promoting wound re-epithelialization, and ensuring ...
Yanyan Lin, Jie Zheng, Xiaobin Lan
doaj +2 more sources
Characterization of patients with dystrophic epidermolysis bullosa for collagen VII therapy. [PDF]
Br J Dermatol, 2015 Dystrophic EB (DEB) is a blistering skin disease caused by mutations in the gene (COL7A1) encoding type VII collagen (C7). DEB can be inherited by either dominant (DDEB) or recessive (RDEB) mechanisms. RDEB results in severe wounds and scarring, as well as extracutaneous manifestations such as esophageal strictures, chronic anemia, and pseudosyndactyly.
Gorell ES +4 more
europepmc +4 more sources
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness [PDF]
The Journal of Clinical InvestigationThe interaction between cells and extracellular matrix (ECM) has been recognized in the mechanism of fibrotic diseases. Collagen type VII (collagen VII) is an ECM component that plays an important role in cell-ECM interaction, particularly in cell ...
Qian Li +16 more
doaj +2 more sources
High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV
Biochemical and Biophysical Research Communications, 2006 Anchoring functions of collagen VII depend on its ability to form homotypic fibrils and to bind to other macromolecules to form heterotypic complexes. Biosensor-based binding assays were employed to analyze the kinetics of the NC1 domain-mediated binding of collagen VII to laminin 5, collagen IV, and collagen I.
Andrzej Fertala, Jouni Uitto
exaly +4 more sources
Collagen VII plays a dual role in wound healing. [PDF]
J Clin Invest, 2013 Although a host of intracellular signals is known to contribute to wound healing, the role of the cell microenvironment in tissue repair remains elusive. Here we employed 2 different mouse models of genetic skin fragility to assess the role of the basement membrane protein collagen VII (COL7A1) in wound healing.
Nyström A +5 more
europepmc +5 more sources
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo [PDF]
Matrix Biology, 2022 Andrew P South, John S McGrath
exaly +2 more sources
Global remodelling of cellular microenvironment due to loss of collagen VII
Molecular Systems Biology, 2013 The mammalian cellular microenvironment is shaped by soluble factors and structural components, the extracellular matrix, providing physical support, regulating adhesion and signalling.
Victoria Küttner +7 more
doaj +4 more sources
Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes [PDF]
Cell Transplantation, 2019 Dorothy M Supp +2 more
exaly +2 more sources