Results 251 to 260 of about 1,462,869 (311)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Thr-to-Ala Mutation Leads to a Larger Aromatic Pair and Reduced Packing Density in α1,α3-Helices during Thioredoxin Cold Adaptation. [PDF]

ACS Omega
Nguyen TA, Lee C.
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

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Cold-Adapted Enzymes

Annual Review of Biochemistry, 2006
By far the largest proportion of the Earth's biosphere is comprised of organisms that thrive in cold environments (psychrophiles). Their ability to proliferate in the cold is predicated on a capacity to synthesize cold-adapted enzymes. These enzymes have evolved a range of structural features that confer a high level of flexibility compared to ...
Khawar Sohail, Siddiqui, Ricardo, Cavicchioli   +1 more
openaire   +2 more sources

Cold Adaptation of Tropomyosin

Biochemistry, 2011
The conformational stability of unphosphorylated and phosphorylated α,α-striated tropomyosins from rabbit and shark (95% identical sequences) has been investigated. Three additional core positions are occupied by atypical amino acids in the protein from shark: Thr179(d), Ser190(a), and Ser211(a).
Michael, Hayley, Tatiana, Chevaldina, David H, Heeley   +2 more
openaire   +2 more sources

Human whole body cold adaptation

Temperature, 2016
Reviews on whole body human cold adaptation generally do not distinguish between population studies and dedicated acclimation studies, leading to confusing results.
Hein A M Daanen, Wouter D Van Marken Lichtenbelt   +1 more
exaly   +2 more sources

Cold adapted enzymes

2000
The number of reports on enzymes from cold adapted organisms has increased significantly over the past years, and reveals that adaptive strategies for functioning at low temperature varies among enzymes. However, the high catalytic efficiency at low temperature seems, for the majority of cold active enzymes, to be accompanied by a reduced thermal ...
A O, Smalås, H K, Leiros, V, Os, N P, Willassen   +3 more
openaire   +2 more sources

Cold-adaptation of human rotavirus

Virus Research, 1987
A human rotavirus strain was cold-adapted for possible future use as a live vaccine. The original strain was isolated in 1980 in primary cynomolgus monkey kidney cells and has a serotype I and subgroup II antigenicity. The virus was serially passaged in African green monkey kidney cells; it was cultivated at 37 degrees C at the first stage of passages,
S, Matsuno, S, Murakami, M, Takagi, M, Hayashi, S, Inouye, A, Hasegawa, K, Fukai   +6 more
openaire   +2 more sources

Cold‐Adapted Nanozymes

Advanced Healthcare Materials
AbstractCold‐adapted nanozymes represent a distinct class of nanomaterials that exhibit robust catalytic activity and stability under low‐temperature conditions (below 37 °C). By emulating the catalytic functions of natural enzymes, these nanozymes can overcome the inherent limitations of traditional enzymes, which typically suffer from the reduced ...
Tianye Zhang, Mengtian Lu, Yue Yang, Xiaoyang Ji, Hao Gu, Yuan Sun, Chunxia Chen, Tiedong Sun   +7 more
openaire   +2 more sources

The Neanderthal face is not cold adapted

Journal of Human Evolution, 2011
Many morphological features of the Pleistocene fossil hominin Homo neanderthalensis, including the reputed large size of its paranasal sinuses, have been interpreted as adaptations to extreme cold, as some Neanderthals lived in Europe during glacial periods.
Todd C, Rae, Thomas, Koppe, Chris B, Stringer   +2 more
openaire   +2 more sources