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Cold-adapted influenza vaccines

Current Opinion in Pediatrics, 2002
Because of the health impact of complicated disease from influenza in children, the role played by children in spreading influenza, and the limitations of inactivated influenza vaccine in this population, there has been ongoing effort to identify a more effective and acceptable vaccine.
John, Bradshaw, Peter F, Wright
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Cold adaptation of microorganisms

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1990
Abstract Psychrophilic and psychrotrophic microorganisms are important in global ecology as a large proportion of our planet is cold (below 5 °C); they are responsible for the spoilage of chilled food and they also have potential uses in low-temperature biotechnological processes.
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Importance of noradrenaline in cold adaptation

American Journal of Physiology-Legacy Content, 1964
Noradrenaline (300 µg/kg) was injected daily for 45 days in a group of 15 rats. At the end of this period O2 consumption and rectal temperature responses to noradrenaline (200 µg/kg) were measured at 30 C in these animals as well as in cold-acclimated and control groups.
J, LEBLANC, M, POULIOT
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Cold-adapted archaea

Nature Reviews Microbiology, 2006
Many archaea are extremophiles. They thrive at high temperatures, at high pressure and in concentrated acidic environments. Nevertheless, the largest proportion and greatest diversity of archaea exist in cold environments. Most of the Earth's biosphere is cold, and archaea represent a significant fraction of the biomass.
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Cold-adapted enzymes

Trends in Biotechnology, 1997
It is an article of faith among biochemists and molecular biologists that precious enzymes must be stored on ice. The usual reason given is that, at temperatures around freezing, enzyme activity is minimized and protein stability maximized. There is considerable evidence supporting this, but is it true for all enzymes? What about enzymes from organisms
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Cold-adapted Euplotes Pheromones

European Journal of Protistology, 2003
Species of Euplotes rely on diffusible signal proteins (pheromones) to promote their mitotic reproduction and mating (sexual) phenomena. Two of these pheromones have recently been structurally characterized from an Antarctic species, E. nobilii, and their amino acid sequences (of 52 and 60 residues, and eight cysteines) were found to be closely related
C. ALIMENTI   +3 more
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Cold Adaptation and Thyroid Hormone Metabolism

Hormone and Metabolic Research, 2005
Resting oxygen consumption and energy expenditure is sensitive to slight alterations in thyroid function. This means that timing and magnitude of cold adaptation would to some extent depend on thyroid function. Local thyroid hormone metabolism is important for energy expenditure and dissipation of heat in special tissues.
Laurberg, P.   +2 more
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Cold adaptation in marine organisms

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1990
Abstract Animals from polar seas exhibit numerous so called resistance adaptations that serve to maintain homeostasis at low temperature and prevent lethal freezing injury. Specialization to temperatures at or below 0 °C is associated with an inability to survive at temperatures above 3-8 °C.
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Cold Adaptation of Triosephosphate Isomerase

Biochemistry, 2017
The main problem for enzymes from psychrophilic species, which need to work near the freezing point of liquid water, is the exponential decay of reaction rates as the temperature is decreased. Cold-adapted enzymes have solved this problem by shifting the activation enthalpy-entropy balance for the catalyzed reaction compared to those of their ...
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Cold adaptation and the human face

American Journal of Physical Anthropology, 1970
AbstractA framework is suggested within which the evolutionary biology of the human head and face can be explored; it includes several channels of natural and behavioral selection as well as modes of “plasticity” change.One aspect of the model is then examined by means of physiological and anthropometric experimentation.
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