Results 51 to 60 of about 1,462,869 (311)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

A CALB-like Cold-Active Lipolytic Enzyme from Pseudonocardia antarctica: Expression, Biochemical Characterization, and AlphaFold-Guided Dynamics

Marine Drugs
Cold-active lipolytic enzymes enable low-temperature biocatalysis, but remain underexplored in Antarctic actinomycetes. Here, we report the discovery and first-step characterization of a CALB-like cold-active lipolytic enzyme (PanLip) from Pseudonocardia
Lixiao Liu, Hackwon Do, Jong-Oh Kim, Jun Hyuck Lee, Hak Jun Kim   +4 more
doaj   +1 more source

Predicting the Suitable Geographical Distribution of Sinadoxa Corydalifolia under Different Climate Change Scenarios in the Three-River Region Using the MaxEnt Model

Plants, 2020
Sinadoxa corydalifolia is a perennial grass with considerable academic value as a rare species owing to habitat destruction and a narrow distribution. However, its distribution remains unclear.
Xiaotao Huang, Li Ma, Chunbo Chen, Huakun Zhou, Buqing Yao, Zhen Ma   +5 more
doaj   +1 more source

Supporting Integrated and Comprehensive Approaches to Climate Change Adaptation in Africa [PDF]

, 2010
The Africa Adaptation Programme (AAP) has been designed to support the long-term efforts of targeted countries to further develop their capability to successfully identify, design and implement holistic adaptation and disaster risk reduction programmes ...
The Africa Adaptation Programme (AAP)
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cold adaptation, aging, and Korean women divers haenyeo

Journal of Physiological Anthropology, 2017
Background We have been studying the thermoregulatory responses of Korean breath-hold women divers, called haenyeo, in terms of aging and cold adaptation.
Joo-Young Lee, Joonhee Park, Siyeon Kim
doaj   +1 more source

Cold Adaptation Strategies and the Potential of Psychrophilic Enzymes from the Antarctic Yeast, Glaciozyma antarctica PI12

Journal of Fungi, 2021
Psychrophilic organisms possess several adaptive strategies which allow them to sustain life at low temperatures between −20 to 20 °C. Studies on Antarctic psychrophiles are interesting due to the multiple stressors that exist on the permanently cold ...
Nur Athirah Yusof, Noor Haza Fazlin Hashim, Izwan Bharudin   +2 more
doaj   +1 more source

Valuing adaptation under rapid change [PDF]

, 2013
The methods used to plan adaptation to climate change have been heavily influenced by scientific narratives of gradual change and economic narratives of marginal adjustments to that change.
Celeste Young, John Handmer, Roger N Jones   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Alpine meadow degradation regulates soil microbial diversity via decreasing plant production on the Qinghai-Tibetan Plateau

Ecological Indicators
In recent decades, alpine meadows have experienced severe degradation owing to external disturbances. Although soil microorganisms are critical for ecosystem services, little is known about their responses to soil degradation and the potential patterns ...
Yu Sun, Xiujuan Zhang, Yongsheng Yang, Yuheng Zhang, Junbang Wang, Mingyang Zhang, Chu Wu, Junliang Zou, Huakun Zhou, Jiexia Li   +9 more
doaj   +1 more source