Results 71 to 80 of about 187,838 (300)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cold-Adapted High Electron Transport Rate in the Photosynthesis of Ice Algal Community [PDF]
, 2016 第4回極域科学シンポジウム個別セッション：[OB] 生物圏11月12日（火）13:00-14:00 国立国語研究所 ...
吉田 和広 +3 more
core +1 more source
Experimental Biology and Medicine, 1963 SummaryRats exposed to cold (6°C) for one month show a very rapid and sustained increase in urinary histamine. At the end of this period animals develop a certain tolerance to histamine aerosols. This modification in histamine excretion in the cold possibly reflects mast cell changes and the decreased sensitivity to this amine in cold adapted animals ...
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2020 Introduction. Chickenpox poses a significant public health concern due to its worldwide occurrence, a substantial probability of severe clinical progression, development of complications that can lead to a fatal outcome.
Firaya G. Nagieva +4 more
doaj +1 more source
Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]
, 2012 Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller +41 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Diversity of cold-adapted ciliates from glacier snow and cryoconite in Arctic region [PDF]
, 2016 第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月18日（金） 統計数理研究所 ...
Fujii Yoshiyuki +6 more
core +1 more source