Results 111 to 120 of about 380,192 (309)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Jixie qiangdu, 2017 Cold extrusion technology is a kind of high precision,efficient,high quality and low cost advanced production technology,in the modern production plays an important role.
WANG LiBo, LIU Yu, WANG Yu, QIN Yi
doaj
Numerical Analysis of Circular Pre-notched U-Channel Section Distortions in Cold Roll-Forming Process [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2017 Cold roll forming is a process in which a metal sheet gets a desired section form by passing through a series of rotating rollers. Predicting the amount of the distortion in pre-notched cold formed sections still remains challenging in cold roll forming ...
S. Sattar, S. Mazdak, E. Sharifi
doaj
CROSS SCALE ANALYSIS FOR THE EFFECT OF PROCESS PARAMETERS ON THE GRAIN SIZE OF COLD ROLLING SPLINE
Jixie qiangdu, 2021 Multi field and cross scale analysis is helpful to improve the forming quality and analyze the evolution law of microstructure in the process of spline forming, which has a very important guiding significance for process optimization, quality prediction ...
WANG Yong +5 more
doaj
Recent Achievements in Numerical Simulation in Sheet Metal Forming Processes
, 2007 Purpose of this paper: During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry.
Tisza, Miklós
core
Controlled nucleation method: a new process for semisolid metal forming [PDF]
, 2005 Semisolid metal forming requires special feedstock material with a fine-grained and globular structure to achieve thixotropic properties. A number of methods have been developed to produce such feedstock materials. Controlled Nucleation Method (CNM) is a
Wang, Hao
core
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source