Results 91 to 100 of about 380,192 (309)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Surface accuracy achieved by upsetting of preforms generated by laser rod end melting
MATEC Web of Conferences, 2015 Cold forming generally allows the reproduction of parts with a high production rate and low waste of material. For this reason, many small parts for example of the body of a smartphone undergo at least one forming operation during their fabrication, e.g.
Brüning Heiko, Vollertsen Frank
doaj +1 more source
Fatigue life improvement in fatigue-aged fastener holes using the cold expansion technique [PDF]
, 2003 The use of cold expansion process as a life extension technique on aircraft structural joints was investigated. The primary focus was an experimental test programme consisting of open-hole and low-load transfer joint specimens made of 2024-T351 ...
Wang, Z., Zhang, Xiang
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2006 Largely applied to internal threading of extruded tubes, cold form tapping is now becoming a promising process for internal threading of holes in non ferrous and ferrous solid components, more particularly for mass production in the automotive industry ...
JULIEN, Benoit +4 more
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Investigation of advanced strain-path dependent material models for sheet metal forming simulations [PDF]
, 2006 Sheet metal forming processes often involve complex loading sequences. To improve the prediction of some undesirable phenomena, such as springback, physical behavior models should be considered.
BALAN, Tudor +5 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Effect of Annealing on The Forming Ability for Brass Sheet
Journal of Engineering and Sustainable Development, 2013 This research deals with the effect of annealing on the cold forming of brass sheets. In this research two methods were chosen one of them is an experimental work and the other is a numerical work. The material used is a brass sheet. Sets of specimens
Ahmed . S. Abdulaziz, Sael S. Al jameel
doaj
Modelling hot (metal) sheet forming with cold tooling
, 2012 Use of cold tooling is beneficial in the sheet metal forming. This paper presents simulations of the process with the objective of investigating issues associated with thermal management, and of providing thermo-mechanical data for future ...
Spence, Julian +4 more
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