Results 71 to 80 of about 380,192 (309)

Prediction and Prevention of Edge Waves in Continuous Cold Forming of Thick-Wall High-Strength Welded Pipe

Metals
In order to reduce the edge waves and defects of the strip in the forming process and obtain better properties of the strip, it is urgent to establish a better flexible cold forming process.
Shengde Hu, Junhao Zhao, Yu Liu
doaj   +1 more source

On the Intermediate Annealing during Cold Forming Process of Steel

Journal of the Society of Materials Science, Japan, 1966
Although annealing at around 700°C (below A1) is commonly recommended as the intermediate annealing during cold forming processes of steels, sometimes it does not necessarily gain satisfactory results, because the cold forming is generally heterogeneous deformation of steel.
openaire   +2 more sources

Numerical simulation on chain-die forming of an AHSS top-hat section [PDF]

, 2018
The applications of Advanced High-Strength Steels (AHSS) in the automotive industry are rapidly increasing due to a demand for a lightweight material that significantly reduces fuel consumption without compromising passenger safety. Automotive industries
Ding, Scott, Raju Majji, Xiang, Yang (R8881), Yang Xiang, Yang, Chunhui (R16973), Yang, Chunhui, Majji, Raju (R19145), Majji, Raju, Xiang, Yang, Scott Ding, Chunhui Yang   +10 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The influence of process parameters and sheet material on the temperature development in the forming zone

Manufacturing Review, 2019
Cold metal forming is a fast and economical way of producing a wide range of precise components. Its profitability mainly depends on part quality, process stability, and service intervals of tools.
Tröber Philipp, Welm Markus, Weiss Hannes Alois, Demmel Peter, Golle Roland, Volk Wolfram   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Finite element simulation of stretch forming of aluminium-polymer laminate foils used for pharmaceutical packaging

MATEC Web of Conferences, 2016
Pharmaceutical high barrier blister packages are manufactured from aluminium-polymer laminate foils (e.g. consisting of PA-Al-PVC layers). By a cold stretch forming process cavities are formed.
Müller Simon, Weygand Sabine M.
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of Vibrations on Metal Forming Process: Analytical Approach and Finite Element Simulations

, 2010
Vibration assisted forming is one of the most recent and beneficial technique used to improve forming process. Effects of vibration on metal forming processes can be attributed to two causes.
ABBA, Gabriel, KHAN, Armaghan, GIRAUD-AUDINE, Christophe, BIGOT, Régis   +3 more
core