Results 61 to 70 of about 380,192 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Numerical Simulation and Experimental Research on Cold Form Tapping Process of Internal Thread [PDF]

open access: yesManufacturing Technology, 2017
During the cold form tapping process of internal thread in high-strength-steel, the effect of bottom-diameter, extrusion speed, friction factor and extrusion times on extrusion temperature and torque have contributed to tap wear, break and manufacturing quality. The process of cold form tapping of internal thread for Q460 high-strength-steel is studied
Hong Miao   +5 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Selected Properties of Input Stock Material for the Production of Thin-Walled Cylindrical Products by Cold Flow Forming [PDF]

open access: yesProblemy Mechatroniki, 2019
This paper presents test results for the steel grade 15HGMV metallurgical purity, microstructure, method of production and effect on the mechanical performance of the input stock material for calibre 227 mm missile motor casings manufactured by cold flow
Marek BURDEK   +6 more
doaj   +1 more source

Microstructure Evolution and Material Flow of Steel in Semi-solid Forming Process [PDF]

open access: yes, 2011
The present study aims to identify and characterize the development of microstructure and deformation characteristics of steel grades in semi-solid state which is affected by the change in morphologies of microstructure at high temperature ...
GU, Guochao   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A New Cold Rotary Forging Technology for Automotive Starter Guiding Cylinder with Internal Helical Involute Spline

open access: yesMATEC Web of Conferences, 2016
A new cold rotary forging technology of the internal helical involute spline was presented based on an analysis of the structure of automotive starter guide cylinder. 3D rigid-plastic finite element model was employed.
Wang Ping, Dong Xiao Fei
doaj   +1 more source

Research on the Production Process of High-Strength Products from Aluminum-Magnesium Alloys for their Direct Processing into Sheets Via Cold Rolling [PDF]

open access: yesArchives of Metallurgy and Materials, 2019
Modern metal forming processes of non-ferrous metals, particularly aluminum and its alloys, are increasingly based on integrated technologies combining numerous operations in one process line. The subject of this paper focuses on the possibility of using
W. Ściężor   +5 more
doaj   +1 more source

The optimisation of shot peen forming processes

open access: yes, 2008
An optimisation method based on an effective process model is presented. The calibrated and verified process model simulates peening on realistic components and provides a non-linear relationship between peening parameters and deflections.
Wu, J, Wang, T, Platts, MJ
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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