Results 51 to 60 of about 12,584,658 (247)
International Journal of Lightweight Materials and Manufacture, 2018 Aluminium alloys are being increasingly utilised in the automotive and aerospace industries to reduce the weight of vehicles. Extensive research has been conducted to overcome the poor ductility of aluminium alloys at room temperature and improve ...
Kailun Zheng +3 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
RESEARCH ON THE IMPACT OF FRICTION COEFFICIENT TO SCALE IN COLD ROLL-BEATING FORMING
Jixie qiangdu, 2017 Scale of forming surface in cold roll-beating forming process is a major defect. Controlling scaly defects is an important method to improve forming surface quality.
FENG JingMin +3 more
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Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
On the Intermediate Annealing during Cold Forming Process of Steel
Journal of the Society of Materials Science, Japan, 1966 Although annealing at around 700°C (below A1) is commonly recommended as the intermediate annealing during cold forming processes of steels, sometimes it does not necessarily gain satisfactory results, because the cold forming is generally heterogeneous deformation of steel.
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Analysis of Innovative Incremental Cold Forming Process for the Manufacturing of Aerospace Rotating Parts [PDF]
Volume 1: Processes, 2017 Cold rotary forging is an innovative incremental metal forming process whose main characteristic is that the workpiece is only partially in contact with a conical tool, reducing therefore the required forging loads. However, in spite of many benefits of such a process, wide industrial implementation of rotary forging is not possible without proper ...
openaire +3 more sources
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Selected Properties of Input Stock Material for the Production of Thin-Walled Cylindrical Products by Cold Flow Forming [PDF]
Problemy Mechatroniki, 2019 This paper presents test results for the steel grade 15HGMV metallurgical purity, microstructure, method of production and effect on the mechanical performance of the input stock material for calibre 227 mm missile motor casings manufactured by cold flow
Marek BURDEK +6 more
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