Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Coating-substrate-simulations applied to HFQ® forming tools
MATEC Web of Conferences, 2015 In this paper a comparative analysis of coating-substrate simulations applied to HFQTM forming tools is presented. When using the solution heat treatment cold die forming and quenching process, known as HFQTM, for forming of hardened aluminium alloy of ...
Leopold Jürgen +2 more
doaj +1 more source
Experimental Research and Numerical Modelling of the Cold Forming Process of the Inconel 625 Alloy Sheets Using Flexible Punch. [PDF]
Materials (Basel), 2023 Balcerzak M +6 more
europepmc +1 more source
Product–process interface for manufacturing data management as a support for DFM and virtual manufacturing [PDF]
, 2008 This research work was supported by SNECMA as part of the MAIA ( http://www.le-webmag.com/article.php3?id_ article=2&lang=) project, the Region Champagne-Ardennes and Sisson Lehmann of the Wheelabrator group.In order to tackle a continuous improvement of
Jawhar Elgueder +8 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Numerical simulation of cold forging process to investigate folding defect in enclosed dies
Mechanics and Advanced Technologies, 2017 In the precision forging industries, improving product quality and reducing product cost are important cases. Enclosed-die forging is one of the precision forging processes.
Payman Abhari
doaj +1 more source
Integrated Process Simulation and Die Design in Sheet Metal Forming
, 2007 During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry. This emerging role is strongly emphasized by the rapid
Lukács, Zsolt, Tisza, Miklós, Gál, G.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Validation of the New Mix Design Process for Cold In-Place Rehabilitation Using Foamed Asphalt, 2007
, 2007 Asphalt pavement recycling has grown dramatically over the last few years as a viable technology to rehabilitate existing asphalt pavements. Iowa's current Cold In-place Recycling (CIR) practice utilizes a generic recipe specification to define the ...
core
A simplified rate dependent model of forming and wrinkling of pre-impregnated woven composites [PDF]
, 2007 A simplified finite element model is developed and validated for the forming/ draping of pre-impregnated woven composites, incorporating the effects of wrinkling and strain rate dependence. The model development builds upon previous work on simulation
Monroy, Aceves C. +2 more
core +1 more source