Results 81 to 90 of about 12,584,658 (247)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Process and Properties on the Precision Forming of Spline Cold Rolling

, 2010
Cold rolling precision forming process of spline is one of the high-efficiency, precision and non-chip forming advanced manufacturing technologies. It has the characteristics such as high forming efficiency, energy-saving, low material consumption and ...
Yong Tang Li, Zhi Qi Liu, Ming Fu Wang, Xu Dong Li, Jian Li Song   +4 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Use of macros in the cold forming tool design process [PDF]

, 2020
V orodjarstvu strmijo k večji produktivnosti in kvaliteti izdelkov. Konstruiranje orodja je ključna operacija pri celotnem postopku izdelave orodja za hladno preoblikovanje, zato smo v diplomskem delu analizirali uporabo mákrojev v procesu razvoja ...
Knez, Anže
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Surface accuracy achieved by upsetting of preforms generated by laser rod end melting

MATEC Web of Conferences, 2015
Cold forming generally allows the reproduction of parts with a high production rate and low waste of material. For this reason, many small parts for example of the body of a smartphone undergo at least one forming operation during their fabrication, e.g.
Brüning Heiko, Vollertsen Frank
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Effect of Annealing on The Forming Ability for Brass Sheet

Journal of Engineering and Sustainable Development, 2013
This research deals with the effect of annealing on the cold forming of brass sheets. In this research two methods were chosen one of them is an experimental work and the other is a numerical work. The material used is a brass sheet. Sets of specimens
Ahmed . S. Abdulaziz, Sael S. Al jameel
doaj  

Investigation and Application of Cold Extrusion Forming Process in Die Structure Design of Plug Extremity

, 2010
a cold extrusion forming process in die structure of plug extremity is analyzed in this paper, its technological data on the tooling structure design of plug extremity are discussed, and the die architecture design and key technology in the automatic ...
Zhi Qiang Jiang, Xian Zhang Feng, Xi Lan Feng   +2 more
core   +1 more source