Results 101 to 110 of about 1,972,874 (316)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1

Nature Communications
Exposure to pathogens throughout a lifetime influences immunity and organ function. Here, we explore how the systemic host-response to bacterial urinary tract infection (UTI) induces tissue-specific alterations to the mammary gland.
Samantha Henry, Steven Macauley Lewis, Samantha Leeanne Cyrill, Mackenzie Kate Callaway, Deeptiman Chatterjee, Amritha Varshini Hanasoge Somasundara, Gina Jones, Xue-Yan He, Giuseppina Caligiuri, Michael Francis Ciccone, Isabella Andrea Diaz, Amelia Aumalika Biswas, Evelyn Hernandez, Taehoon Ha, John Erby Wilkinson, Mikala Egeblad, David Arthur Tuveson, Camila Oresco dos Santos   +17 more
doaj   +1 more source

The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly

Cell Reports, 2017
Summary: RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known as ...
An-Yun Chang, Stephane E. Castel, Evan Ernst, Hyun Soo Kim, Robert A. Martienssen   +4 more
doaj   +1 more source

Bikini Kill, Team Dresch, Bloodroot, and Cold Cold Hearts concert flier, George Washington University, Washington, D.C., February 26, 1996

, 1996
Flier promoting a concert by the punk bands Bikini Kill, Team Dresch, Bloodroot, and Cold Cold Hearts. The concert occurred at George Washington University's Marvin Center Ballroom in Washington, D.C. on February 26, 1996.
Positive Force DC
core  

"Hi-e" -cold feeling- of citizens

, 2010
"Hi-e" (cold feeling ) was analyzed among women above13 years-old in G-city. 200 sets of questionnaire were delivered by hand or posting to each home and 107 sets were answered by mail or by hand. 91 answers were analyzed. People suffering from "hi-e" is
Aoki, Takako, Kuroki, Yukiko, 青木, 貴子, アオキ, タカコ, 黒木, 由希子, クロキ, ユキコ   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Massive multiplexing of spatially resolved single neuron projections with axonal BARseq

Nature Communications
Neurons in the cortex are heterogeneous, sending diverse axonal projections to multiple brain regions. Unraveling the logic of these projections requires single-neuron resolution.
Li Yuan, Xiaoyin Chen, Huiqing Zhan, Gilbert L. Henry, Anthony M. Zador   +4 more
doaj   +1 more source

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

eLife, 2017
The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK block the proliferation of various cancer cell lines, and MELK knockdown has been ...
Ann Lin, Christopher J Giuliano, Nicole M Sayles, Jason M Sheltzer   +3 more
doaj   +1 more source

Reliability analysis of two-unit cold standby repairable systems under Poisson shock. [PDF]

, 2011
This paper analyses the reliability of a cold standby system consisting of two re- pairable units, a switch and a repairman. At any time, one of the two units is operating while the other is on cold standby.
Shaomin Wu, Wu, Shaomin, Qingtai Wu, Wu, Qingtai   +3 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source