Results 81 to 90 of about 2,218,582 (300)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Electrophysiological characterisation of neuronal components of cold sensitivity [PDF]
, 2015 Aberrant cold sensitivity is apparent in several neuropathies of peripheral and central origin, and is poorly treated by currently available drugs.
Patel, R
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Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram
Nature CommunicationsReticulate leaf venation, characterized by the presence of loops, is a distinguishing feature of many flowering plants. However, our understanding of both the geometry and the morphogenesis of reticulate vein patterns is far from complete.
CiCi Xingyu Zheng +8 more
doaj +1 more source
Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Cell Reports, 2018 Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference.
Adam Naguib +14 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Regionalized feasibility study of cold weather earthwork
, 2020 Special Report 76-2 REGIONALIZED FEASIBILITY STUDY OF COLD WEATHER EARTH WORK William S. Roberts July 1976 Prepared for DIRECTORATE OF MILITARY CONSTRUCTION OFFICE, CHIEF OF ENGINEERS , CORPS OF ENGINEERS, U.S. ARMY OOl.D REGIONS RESEARCH AND ENGINEERING
Cold Regions Research and Engineering Laboratory (U.S.);
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Nature CommunicationsTranscriptional silencing by RNAi paradoxically relies on transcription, but how the transition from transcription to silencing is achieved has remained unclear.
Hyun-Soo Kim +7 more
doaj +1 more source