Results 71 to 80 of about 1,972,874 (316)

Low Fatigue Response of Crest-Fixed Cold-Formed Steel Drape Curved Roof Claddings

, 2018
Cold-formed steel roof claddings are subjected to significant suction/uplift pressures during high wind events. In New Zealand, the strong prevailing winds makes this a common occurrence. Suction pressures are generated by the turbulence of the wind flow
Lim, J. B., Roy, Krishanu, Mahendran, Mahen, Roy, K., Yousefi, Amir Mohammad, Clifton, G. Charles, Mahendran, M., Yousefi, Amir M. (R20392), Clifton, G. C., Lim, James B. P.   +9 more
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Corrosion performance of laser post-treated cold sprayed titanium coatings [PDF]

, 2011
The recent development of cold spray technology has made possible the deposition of highly reactive,oxygen sensitive materials, such as titanium, without significant chemical reaction of the powder, modificationof particle microstructure and with minimal
Marrocco, T., D. G. McCartney, Shipway, P. H., McCartney, D. G., Hussain, Tanvir, P. H. Shipway, T. Marrocco, T. Hussain   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Cold Cold Hearts concert flier - Stinkweeds Records, Phoenix, Arizona, June 25, 1996

, 1996
Flier advertising a concert by Washington, D.C. punk band the Cold Cold Hearts and the Canadian hardcore punk band Republic of Freedom Fighters. The concert occurred at Stinkweeds Records in Phoenix, Arizona on June 25, 1996.

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Enhanced levels of cold shock proteins in Listeria monocytogenes LO28 upon exposure to low temperature and high hydrostatic pressure

, 2002
Listeria monocytogenes is a psychrotrophic food-borne pathogen that is problematic for the food industry because of its ubiquitous distribution in nature and its ability to grow at low temperatures and in the presence of high salt concentrations.
Karatzas, Andreas K., Wouters, J.A., Abee, T., Wemekamp-Kamphuis, H.H., Wemekamp-Kamphuis, Henrike H., Karatzas, A.K., Wouters, Jeroen A., Abee, Tjakko   +7 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation

Nature Communications
Transcriptional silencing by RNAi paradoxically relies on transcription, but how the transition from transcription to silencing is achieved has remained unclear.
Hyun-Soo Kim, Benjamin Roche, Sonali Bhattacharjee, Leila Todeschini, An-Yun Chang, Christopher Hammell, André Verdel, Robert A. Martienssen   +7 more
doaj   +1 more source

WSN based intelligent cold chain management

, 2008
This paper presents a cold chain monitoring system which is implemented by using ubiquitous computing technologies, Radio Frequency Identification (RFID) & Wireless Sensor Network (WSN).
Fu, W, Chang, YS, Aung, MM, Makatsoris, C, Oh, CH   +4 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source