Results 91 to 100 of about 2,154,939 (308)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Inter- and intra-specific genomic divergence in Drosophila montana shows evidence for cold adaptation

, 2018
The genomes of species that are ecological specialists will likely contain signatures of genomic adaptation to their niche. However, distinguishing genes related to their ecological specialism from other sources of selection and more random changes is a ...
M. Kankare, V. I. Tyukmaeva, D. J. Parker, R. K. Butlin, R. A. W. Wiberg, A. Hoikkala, M. G. Ritchie, U. Trivedi, K. Gharbi   +8 more
core   +1 more source

Isolation and cellular fatty acid composition of psychrotrophic Halomonas strains from Antarctic sea water [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2013
Microorganisms from extreme environments such as Arctic, Antarctic and Polar regions modulate their membrane fatty acids to survive in such habitats. Characterization of such microorganisms helps in understanding their physiological behavior.
Vipra Vijay Jadhav, Amit Yadav, Yogesh S. Shouche, Rama Kaustubh Bhadekar   +3 more
doaj  

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

The Content and Reporting Completeness of Physical Therapist–Led Interventions for Glenohumeral Osteoarthritis: A Systematic Review

Arthritis Care &Research, EarlyView.
Objective This study synthesized the content and reporting completeness of published physical therapist–led interventions for glenohumeral osteoarthritis (GHOA). Methods This systematic review undertook electronic database searches in PubMed, EMBASE, Cochrane, CINAHL, and PEDro (until June 2025) for any peer‐reviewed articles or studies describing ...
Daha G. Muhammad, Nadine E. Foster, Mickylle Pelaez, Karina O'Leary, Ilana N. Ackerman, Jonathan G. Quicke   +5 more
wiley   +1 more source

Supporting evidence-based adaptation decision-making in Western Australia: a synthesis of climate change adaptation research [PDF]

, 2013
This research synthesis provides policy-makers and practitioners with an understanding of the building blocks for effective adaptation decision-making, as evidenced through the NCCARF research program.
Laura Cacho, Jennifer Cane, Nicholas Dircks   +2 more
core  

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

Nature Communications
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation.
Xiaomei Zhang, Lihao Ge, Guanghui Jin, Yasong Liu, Qingfen Yu, Weizhao Chen, Liang Chen, Tao Dong, Kiyoharu J. Miyagishima, Juan Shen, Jinghong Yang, Guo Lv, Yan Xu, Qing Yang, Linsen Ye, Shuhong Yi, Hua Li, Qi Zhang, Guihua Chen, Wei Liu, Yang Yang, Wei Li, Jingxing Ou   +22 more
doaj   +1 more source

On the Cold Adaptation

Journal of the Anthropological Society of Nippon, 1978
To investigate the cold adaptability, standard techniques including both methods of local and/or general stimuli were established and introduced by WEINER and LOURIE. The results obtained by this kind of study are of values from the practical as well as the theoretical point of view.
openaire   +2 more sources

dynoGP: Deep Gaussian Processes for Dynamic System Identification

International Journal of Adaptive Control and Signal Processing, EarlyView.
This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli, Marco Forgione, Dario Piga, Marco Zaffalon   +3 more
wiley   +1 more source