Results 181 to 190 of about 55,316 (261)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Comparing the motion of dark matter and standard model particles on cosmological scales. [PDF]

Nat Commun
Grimm N, Bonvin C, Tutusaus I.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Multi-omics and cultivation reveal laminarin-degrading PVC bacteria in the deep sea. [PDF]

Nat Commun
Zheng R, Wang C, Sun C.
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

The quintom theory of dark energy after DESI DR2. [PDF]

Natl Sci Rev
Cai Y, Ren X, Qiu T, Li M, Zhang X.
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

A prototype differential atom interferometer for fundamental physics. [PDF]

Nature
Baynham CFA, Hobson R, Buchmüller O, Evans D, Hawkins L, Iannizzotto Venezze L, Josset A, Lee D, Pasatembou E, Sauer BE, Tarbutt MR, Walker T, Ennis O, Chauhan U, Brzakalik A, Dey S, Hedges S, Stray B, Langlois M, Bongs K, Hird T, Lellouch S, Holynski M, Bostwick B, Chen J, Eyler Z, Gibson V, Harte TL, Hsu CC, Karzazi M, Lu C, Millward B, Mitchell J, Mouelle N, Panchumarthi B, Scheper J, Schneider U, Su X, Tang Y, Tkalčec K, Zeuner M, Zhang S, Zhi Y, Badurina L, Beniwal A, Blas D, Carlton J, Ellis J, McCabe C, Parish G, Govardhan DP, Vaskonen V, Bowcock T, Bridges K, Carroll A, Coleman J, Elertas G, Hindley S, Metelko C, Throssell H, Tinsley JN, Bentine E, Booth M, Bortoletto D, Callaghan N, Foot C, Gómez-Monedero C, Hughes K, James A, Leese T, Lowe A, March-Russell J, Sander J, Schelfhout J, Shipsey I, Weatherill D, Wood D, Balashov SN, Bason MG, Hussain K, Labiad H, Majewski P, Marchant AL, Newbold D, Pan Z, Tam Z, Thornton TC, Valenzuela T, van der Grinten MGD, Wilmut I, Clarke K, Vick A, AION Collaboration.   +92 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Introducing a recycling method for iron oxide from cold forming mild scale and its application in alkyd resin-based primer paint. [PDF]

Sci Rep
Sattari SMP, Kavanlouei M, Khajehmohammadilar SA.   +2 more
europepmc   +1 more source