Results 61 to 70 of about 326,842 (279)

Formation of Multiple Dynamical Classes in the Kuiper Belt via Disk Dissipation

The Astrophysical Journal
Planetesimal formation likely lasted for millions of years in the solar nebula, and the cold classicals in the Kuiper Belt are suggested to be the direct products of streaming instability.
Tommy Chi Ho Lau, Til Birnstiel, Sebastian M. Stammler, Joanna Drążkowska   +3 more
doaj   +1 more source

Mitigation of polycyclic aromatic hydrocarbons (PAHs) in roasted beef patties by cold plasma treatment and products quality evaluation

Food Science and Human Wellness
The cold plasma (CP) technique was applied to alleviate the contamination of polycyclic aromatic hydrocarbon (PAH) in this investigation. Two different CP treatments methods were implemented in the production of beef patties, to investigate their ...
Yuke Hou, Yangjian Hu, Min Li, Jiahui Nong, Fengyuan Xie, Yuhan Fan, Jianhao Zhang, Xianming Zeng, Minyi Han, Xinglian Xu, Xia Wang   +10 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Enhancing steel slag cement mortar performance under low-temperature curing through alkali activation: mechanisms and implications

Frontiers in Materials
The effective utilization of steel slag waste offers a sustainable approach to advancing construction materials, particularly in cold regions. This study investigates the influence of alkaline activators and low-temperature curing (10°C) on the ...
Wei Ye, Tengteng Feng, Wangwen Sun, Lauren Y. Gómez-Zamorano   +3 more
doaj   +1 more source

Diagenetic evolution of some modern and ancient cold seep-carbonates from East Coast Basin, New Zealand.

, 2009
Cold seep-carbonates are the microbially mediated by-products of the anaerobic oxidation of methane (AOM) at seafloor cold seeps, and are widespread about modern continental margins and in the geologic record.
Ewen, Sarah Maree
core  

Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow [PDF]

, 2011
An understanding of the balance between carbon and nitrogen assimilation in plants is key to future bioengineering for a range of applications.
John M. Baker, Baker, J. M., Jane L. Ward, Aimee M. Llewellyn, Michael H. Beale, Hawkins, N. D., Beale, M. H., Llewellyn, A. M., Nathaniel D. Hawkins, Ward, J. L.   +9 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigation of Flow Parameters for Titanium Cold Spraying using CFD Simulation

, 2010
A comprehensive study of cold gas dynamic spray technology is required for optimising performance and gun design for spraying various materials. Cold spraying technology is a new technique in industry and very limited data is available.
Singh, Tejinder
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source