Cell Reports, 2023 Summary: TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund’s adjuvant (CFA ...
Qiao Zhang +8 more
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Journal of Pharmacological Sciences, 2014 Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion.
Meng Zhao +8 more
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Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice. [PDF]
PLoS ONEChemotherapy is often a life-saving treatment, but the development of intractable pain caused by chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity that restricts cancer survival rates.
Emily E Whitaker +3 more
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Bidirectional modulation of somatostatin-expressing interneurons in the basolateral amygdala reduces neuropathic pain perception in mice [PDF]
Frontiers in Pain ResearchIntroductionNeuropathic pain is characterized by mechanical allodynia and thermal (heat and cold) hypersensitivity, yet the underlying neural mechanisms remain poorly understood.MethodsUsing chemogenetic excitation and inhibition, we examined the role of
Aditya Apte +7 more
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The efficacy and safety of Sipjeondaebo-tang in Korean patients with cold hypersensitivity in the hands and feet: a protocol for a pilot, randomized, double-blind, placebo-controlled, parallel-group clinical trial [PDF]
Trials, 2019 Background Cold hypersensitivity in the hands and feet (CHHF) is frequent in Asian countries including Korea. The quality of life can be degraded by the symptoms of CHHF.
Youme Ko +11 more
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Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats. [PDF]
J Neurosci, 2021 Trigeminal neuropathic pain is the most debilitating pain disorder but current treatments including opiates are not effective. A common symptom of trigeminal neuropathic pain is cold allodynia/hyperalgesia or cold hypersensitivity in orofacial area, a ...
Kanda H +7 more
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The cold model of tooth hypersensitivity screening
Эндодонтия Today, 2020 The article considers the stages of creating of the cold model of tooth hypersensitivity screening. The study based on the idea of correlation between tooth hypersensitivity levels and time of ice cream eating as confirmed by the results of the research.
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Cold hypersensitivity in the hands and feet is associated with erectile dysfunction in young Taiwanese men. [PDF]
Sci RepCold hypersensitivity in the hands and feet (CHHF) is a protective or predisposing factor for many diseases; however, the relationship between CHHF and erectile dysfunction (ED) remains unclear.
Chang CJ, Fan YH, Chiu YC, Cheng WM.
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Subcutaneous administration of a novel TRPM8 antagonist reverses cold hypersensitivity while attenuating the drop in core body temperature. [PDF]
Br J PharmacolWe extend the characterization of the TRPM8 antagonist VBJ103 with tests of selectivity, specificity and distribution, therapeutic efficacy of systemic administration against oxaliplatin‐induced cold hyperalgesia and the impact of systemic administration
Gold MS +6 more
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The Relationship between Cold Hypersensitivity in the Hands and Feet and Health-Related Quality of Life in Koreans: A Nationwide Population Survey. [PDF]
Evid Based Complement Alternat Med, 2019 Aim We investigated the distribution of cold hypersensitivity in the hands and feet (CHHF) and examined the association between CHHF and health-related quality of life (HRQOL) among Koreans.
Bae KH, Lee Y, Go HY, Kim SJ, Lee SW.
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