Cold pain hypersensitivity predicts trajectories of pain and disability after low back surgery: a prospective cohort study [PDF]
, 2020 Improving the ability to predict persistent pain after spine surgery would allow identification of patients at risk and guide treatment decisions.
Peter Jüni +21 more
core +4 more sources
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling
Molecular Brain, 2020 Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca +9 more
doaj +1 more source
Assessment of drug hypersensitivity with non-irritating concentrations of antibacterial agents for allergic skin tests: a review [PDF]
, 2014 Hypersensitivity reactions to antibiotics are common with a prevalence of 6-10% of all adverse reactions. There is a lack of guidelines and standardization of skin tests for the screening of hypersensitivity to all antibiotics, in terms of the ...
M. C., Shivamurthy +2 more
core +1 more source
Determination of the Activities Affected Due to Cold Intolerance after Peripheral Nerve Disorders
Bezmiâlem Science, 2023 Objective:Our study was designed to determine the activities affected due to cold intolerance (CI) after peripheral nerve disorders.Methods:Participants aged 18-65 who were diagnosed as having peripheral nerve disorder in the last year and whose ...
Özge Buket ARSLAN, Çiğdem ÖKSÜZ
doaj +1 more source
Comparison of Vantej and Dente 91 Toothpastes in the Management of Dentin Hypersensitivity: A Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Dentinal hypersensitivity is a prevalent and distressing dental condition characterised by acute, transient pain or discomfort arising from exposed dentin in response to external stimuli, such as variations in temperature, mechanical ...
Ramesh Nagarajappa +6 more
doaj +1 more source
Life, 2022 The pathophysiological mechanism underlying migraine-associated peripheral hypersensitivity remains unclear. Acid-sensing ion channels (ASICs) and transient receptor potential ankyrin 1 (TRPA1) are known to be causative pathogenic factors of mechanical ...
Sol-Ji Kim +3 more
doaj +1 more source
Distribution of dentin hypersensitivity by teeth [PDF]
, 2019 Dentin hypersensitivity is a short-term, acute pain that occurs after provoking the dentin with thermal, mechanical, osmotic or chemical irritants in vital teeth.
Panov, Vladimir; Medical University of Varna +1 more
core +5 more sources
Electrophysiological characterisation of neuronal components of cold sensitivity [PDF]
, 2015 Aberrant cold sensitivity is apparent in several neuropathies of peripheral and central origin, and is poorly treated by currently available drugs.
Patel, R
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source