Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice. [PDF]
PLoS ONEChemotherapy is often a life-saving treatment, but the development of intractable pain caused by chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity that restricts cancer survival rates.
Emily E Whitaker +3 more
doaj +3 more sources
The cold model of tooth hypersensitivity screening
Эндодонтия Today, 2020 The article considers the stages of creating of the cold model of tooth hypersensitivity screening. The study based on the idea of correlation between tooth hypersensitivity levels and time of ice cream eating as confirmed by the results of the research.
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The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity [PDF]
Molecular Pain, 2010 Background The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g.
Andersson David A +3 more
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Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera. [PDF]
Eur J Neurosci, 2015 AbstractCold hypersensitivity is evident in a range of neuropathies and can evoke sensations of paradoxical burning cold pain. Ciguatoxin poisoning is known to induce a pain syndrome caused by consumption of contaminated tropical fish that can persist for months and include pruritus and cold allodynia; at present no suitable treatment is available ...
Patel R +3 more
europepmc +11 more sources
TRPA1 Contributes to Cold Hypersensitivity [PDF]
The Journal of Neuroscience, 2010 TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial. Here, we demonstrate that mild cooling markedly increases agonist-evoked rat TRPA1 currents.
Donato, del Camino +17 more
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A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. [PDF]
PLoS ONE, 2013 Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D ...
Jérémy Ferrier +7 more
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Journal of Pharmacological Sciences, 2014 Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion.
Meng Zhao +8 more
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Hypersensitivity in teeth affected by molar-incisor hypomineralization (MIH) [PDF]
Scientific Reports, 2021 Tooth hypersensitivity is a common symptom in patients with molar-incisor hypomineralization (MIH). Therefore, this clinical study aimed to assess potential associations between patient- and tooth-related variables and the intensity of hypersensitivity ...
Thomas Linner +5 more
doaj +2 more sources
Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. [PDF]
PLoS ONE, 2011 TRPM8 (Transient Receptor Potential Melastatin-8) is a cold- and menthol-gated ion channel necessary for the detection of cold temperatures in the mammalian peripheral nervous system.
Wendy M Knowlton +4 more
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Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice [PDF]
Molecular Pain, 2012 Background Oxaliplatin, a platinum-based chemotherapeutic agent, causes an unusual acute peripheral neuropathy. Oxaliplatin-induced acute peripheral neuropathy appears in almost all patients rapidly after infusion, and is triggered or exacerbated by cold,
Zhao Meng +5 more
doaj +2 more sources