Results 51 to 60 of about 1,125,979 (313)

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Prognos (R) in the diagnosis of amalgam hypersensitivity - A diagnostic case-control study [PDF]

, 2007
Objective: We aimed to investigate whether the Prognos (R) device might be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings.
Colbert AP, Hickel R, Langworth S, Leistevuo J, Lindh U, Melchart D, Sagrjadski WA, Schiele R, Schuurs A, Staehle HJ, Stejskal VD, Treugut H   +11 more
core   +1 more source

Minimizing the source of nociception and its concurrent effect on sensory hypersensitivity: An exploratory study in chronic whiplash patients

BMC Musculoskeletal Disorders, 2010
Background The cervical zygapophyseal joints may be a primary source of pain in up to 60% of individuals with chronic whiplash associated disorders (WAD) and may be a contributing factor for peripheral and centrally mediated pain (sensory ...
Stratford Paul, Hooper Allen, Smith Ashley D, Schneider Geoff M, Schneider Kathryn J, Westaway Michael D, Frizzell Bevan, Olson Lee   +7 more
doaj   +1 more source

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability [PDF]

, 2018
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized.
Bennett, David L., Buckley, Camilla, Carroll, Liam, Cervellini, Ilaria, Chisholm, Kim I., Clark, Alex J, Coutinho, Ester, Dawes, John M., Dickenson, Anthony H., Galino, Jorge, Giannoccaro, Maria Pia, Gutierrez-Mecinas, Maria, Iwagaki, Noboru, Jacobson, Leslie, Kuehn, Hannah, Kühnemund, Johannes, Lang, Bethan, Leite, M Isabel, Lewin, Gary R., McMahon, Stephen B., Menassa, David A., Middleton, Steven J., Patel, Ryan, Peck, Liam J., Peles, Elior, Pettingill, Philippa, Sanna, Maria D., Shakir, Akila, Sheridan, Joseph, Tewari, Damini, Themistocleous, Andreas C., Todd, Andrew J., Trendafilova, Teodora, Vincent, Angela, Walcher, Jan, Weir, Greg A., Werynska, Karolina, West, Steven J., Wildner, Hendrik, Zeilhofer, Hanns Ulrich   +39 more
core   +2 more sources

Different Involvement of ASIC and TRPA1 in Facial and Hindpaw Allodynia in Nitroglycerin-Induced Peripheral Hypersensitivities in Mice

Life, 2022
The pathophysiological mechanism underlying migraine-associated peripheral hypersensitivity remains unclear. Acid-sensing ion channels (ASICs) and transient receptor potential ankyrin 1 (TRPA1) are known to be causative pathogenic factors of mechanical ...
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Dae-Hyun Roh   +3 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Cold Hypersensitivity in Raynaud's Phenomenon [PDF]

Circulation, 1971
We have sought evidence that local cooling enhances the adrenergic neurotransmitter mechanism in resistance vessels in the hands of subjects with Raynaud's phenomenon. The method used was to examine the magnitude and time-course of the reflex vasoconstriction in the hand which follows application of ice to the neck. One hand of each subject was kept at
G G, Jamieson, J, Ludbrook, A, Wilson
openaire   +2 more sources

Searching for analgesic drug candidates alleviating oxaliplatin‐induced cold hypersensitivity in mice

Chemical Biology and Drug Design, 2019
Oxaliplatin is a third‐generation, platinum‐based derivative used to treat advanced colorectal cancer. Within the patient population on oxaliplatin therapy, a lower incidence of hematological adverse effects and gastrointestinal toxicity is noted, but ...
K. Sałat, A. Furgala, Natalia Malikowska-Racia   +2 more
semanticscholar   +1 more source

Investigating The Role of AEG-1 in Mouse Models of Pain [PDF]

, 2020
Background: Astrocyte Elevated Gene 1 (AEG-1) is a multifunctional protein shown to be a regulator of transcription and multiple intracellular signaling pathways.
Bagdas, Deniz, Damaj, M. Imad., Mckiver, Bryan, Sarkar, Devanand, Toma, Wisam   +4 more
core   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler, Dirig DM, Hao JX, Hosny A, Imgard Tegeder, Martina Kurejova, Nitin Agarwal, Rohini Kuner, Stefan Brugger, Vijayan Gangadharan   +9 more
core   +3 more sources